Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 839624..840278 Replicon chromosome
Accession NZ_CP101513
Organism Escherichia coli strain HH194M

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag MOO21_RS04105 Protein ID WP_000244777.1
Coordinates 839871..840278 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag MOO21_RS04100 Protein ID WP_000354046.1
Coordinates 839624..839890 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOO21_RS04075 (834793) 834793..835536 + 744 WP_000951962.1 SDR family oxidoreductase -
MOO21_RS04080 (835593) 835593..837026 - 1434 WP_001338826.1 6-phospho-beta-glucosidase BglA -
MOO21_RS04085 (837071) 837071..837382 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
MOO21_RS04090 (837546) 837546..838205 + 660 WP_000250274.1 hemolysin III family protein -
MOO21_RS04095 (838401) 838401..839381 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
MOO21_RS04100 (839624) 839624..839890 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
MOO21_RS04105 (839871) 839871..840278 + 408 WP_000244777.1 protein YgfX Toxin
MOO21_RS04110 (840318) 840318..840839 - 522 WP_001055874.1 flavodoxin FldB -
MOO21_RS04115 (840951) 840951..841847 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
MOO21_RS04120 (841872) 841872..842582 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MOO21_RS04125 (842588) 842588..844321 + 1734 WP_000813201.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T252166 WP_000244777.1 NZ_CP101513:839871-840278 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT252166 WP_000354046.1 NZ_CP101513:839624-839890 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References