Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 543719..544355 Replicon chromosome
Accession NZ_CP101506
Organism Bacillus altitudinis strain B12

Toxin (Protein)


Gene name mazF Uniprot ID K2MHT4
Locus tag NM966_RS02675 Protein ID WP_003214169.1
Coordinates 544005..544355 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID W8QJ31
Locus tag NM966_RS02670 Protein ID WP_003214273.1
Coordinates 543719..544000 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NM966_RS02650 (NM966_02645) 539871..540476 - 606 WP_007496491.1 rhomboid family intramembrane serine protease -
NM966_RS02655 (NM966_02650) 540573..540938 + 366 WP_144610494.1 holo-ACP synthase -
NM966_RS02660 (NM966_02655) 541099..542115 + 1017 WP_007496489.1 outer membrane lipoprotein-sorting protein -
NM966_RS02665 (NM966_02660) 542244..543425 + 1182 WP_017366664.1 alanine racemase -
NM966_RS02670 (NM966_02665) 543719..544000 + 282 WP_003214273.1 hypothetical protein Antitoxin
NM966_RS02675 (NM966_02670) 544005..544355 + 351 WP_003214169.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
NM966_RS02680 (NM966_02675) 544470..545300 + 831 WP_007496484.1 RsbT co-antagonist protein RsbRA -
NM966_RS02685 (NM966_02680) 545305..545673 + 369 WP_003214235.1 RsbT antagonist protein RsbS -
NM966_RS02690 (NM966_02685) 545676..546077 + 402 WP_003214085.1 anti-sigma regulatory factor -
NM966_RS02695 (NM966_02690) 546088..547095 + 1008 WP_017358394.1 PP2C family protein-serine/threonine phosphatase -
NM966_RS02700 (NM966_02695) 547155..547484 + 330 WP_017358393.1 anti-sigma factor antagonist -
NM966_RS02705 (NM966_02700) 547481..547969 + 489 WP_048001251.1 anti-sigma B factor RsbW -
NM966_RS02710 (NM966_02705) 547935..548723 + 789 WP_012009000.1 RNA polymerase sigma factor SigB -
NM966_RS02715 (NM966_02710) 548723..549322 + 600 WP_008346897.1 PP2C family serine/threonine-protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12976.99 Da        Isoelectric Point: 5.1663

>T252162 WP_003214169.1 NZ_CP101506:544005-544355 [Bacillus altitudinis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEINAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDEALQVSLALIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10864.25 Da        Isoelectric Point: 5.2726

>AT252162 WP_003214273.1 NZ_CP101506:543719-544000 [Bacillus altitudinis]
MSESSATNEMKIRLPEALMSEIERVAEQDKVTRNELIYRATKTYIRERNIRQNRESMRRGYMEMAKINLNISSEAQYAEF
EAENTVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K2MHT4

Antitoxin

Source ID Structure
AlphaFold DB A0A081L854

References