Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 388165..388731 Replicon chromosome
Accession NZ_CP101497
Organism Microcella sp. MMS21-STM10

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NNL39_RS01850 Protein ID WP_255160862.1
Coordinates 388165..388530 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag NNL39_RS01855 Protein ID WP_255160012.1
Coordinates 388537..388731 (-) Length 65 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NNL39_RS01820 (NNL39_01820) 384610..385926 + 1317 WP_255160006.1 FAD-dependent oxidoreductase -
NNL39_RS01825 (NNL39_01825) 385960..386382 - 423 WP_255160007.1 DUF1761 domain-containing protein -
NNL39_RS01830 (NNL39_01830) 386459..387034 + 576 WP_255160008.1 1-acyl-sn-glycerol-3-phosphate acyltransferase -
NNL39_RS01835 (NNL39_01835) 387048..387470 + 423 WP_255160009.1 hypothetical protein -
NNL39_RS01840 (NNL39_01840) 387514..387771 - 258 WP_255160010.1 DUF4190 domain-containing protein -
NNL39_RS01845 (NNL39_01845) 387916..388134 + 219 WP_255160011.1 amphi-Trp domain-containing protein -
NNL39_RS01850 (NNL39_01850) 388165..388530 - 366 WP_255160862.1 type II toxin-antitoxin system VapC family toxin Toxin
NNL39_RS01855 (NNL39_01855) 388537..388731 - 195 WP_255160012.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NNL39_RS01860 (NNL39_01860) 389121..390194 - 1074 WP_255160013.1 redox-regulated ATPase YchF -
NNL39_RS01865 (NNL39_01865) 390285..392102 + 1818 WP_255160014.1 gamma-glutamyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-111)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13100.15 Da        Isoelectric Point: 7.0741

>T252159 WP_255160862.1 NZ_CP101497:c388530-388165 [Microcella sp. MMS21-STM10]
MLVDTSVWIDHLHRGERELVRALNTSLVVQHPMVIGELSLGRLRDRSVVLELLGNLPSSPIASHSEVAGFVEVHALYGQG
LSLVDAHLLASVVLAPGTTLWTRDKRLREAANRLGVGASLP

Download         Length: 366 bp

Antitoxin


Download         Length: 65 a.a.        Molecular weight: 6864.67 Da        Isoelectric Point: 5.0022

>AT252159 WP_255160012.1 NZ_CP101497:c388731-388537 [Microcella sp. MMS21-STM10]
MRTTVNLDDDLLAKAAELSGTTERTALLRESLQALIERESARRLSLLGGTDAGATAADRHRDVA

Download         Length: 195 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References