Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 41677..42274 Replicon chromosome
Accession NZ_CP101497
Organism Microcella sp. MMS21-STM10

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag NNL39_RS00200 Protein ID WP_255159712.1
Coordinates 41963..42274 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag NNL39_RS00195 Protein ID WP_255159711.1
Coordinates 41677..41973 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NNL39_RS00165 (NNL39_00165) 38359..38565 + 207 WP_255159706.1 dodecin family protein -
NNL39_RS00170 (NNL39_00170) 38562..38735 - 174 WP_255159707.1 hypothetical protein -
NNL39_RS00175 (NNL39_00175) 38832..39275 - 444 WP_255159708.1 hypothetical protein -
NNL39_RS00180 (NNL39_00180) 39405..40316 + 912 WP_255159709.1 M48 family metallopeptidase -
NNL39_RS00185 (NNL39_00185) 40334..40972 - 639 WP_255159710.1 phenylalanine--tRNA ligase beta subunit-related protein -
NNL39_RS00190 (NNL39_00190) 40979..41590 - 612 WP_255160962.1 LysE family translocator -
NNL39_RS00195 (NNL39_00195) 41677..41973 - 297 WP_255159711.1 putative addiction module antidote protein Antitoxin
NNL39_RS00200 (NNL39_00200) 41963..42274 - 312 WP_255159712.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NNL39_RS00205 (NNL39_00205) 42447..43460 + 1014 WP_255159713.1 hypothetical protein -
NNL39_RS00210 (NNL39_00210) 43457..44143 - 687 WP_255159714.1 vWA domain-containing protein -
NNL39_RS00215 (NNL39_00215) 44140..45648 - 1509 WP_255159715.1 ADP-ribosylglycohydrolase family protein -
NNL39_RS00220 (NNL39_00220) 45802..46713 - 912 WP_255159716.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 40979..53988 13009


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-95)

Antitoxin

Uncharacterized protein HI1420

(6-95)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11719.31 Da        Isoelectric Point: 10.5104

>T252157 WP_255159712.1 NZ_CP101497:c42274-41963 [Microcella sp. MMS21-STM10]
MYELRRSAEFDRWLARLSDRGAVARVLVRLDRLARGNPGDVRPVGFGVSELRIDHGPGLRVYYLQHGGAIVLLLCGGDKS
TQSRDIRRAHRVAEQWRGEKHDD

Download         Length: 312 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10345.58 Da        Isoelectric Point: 4.5535

>AT252157 WP_255159711.1 NZ_CP101497:c41973-41677 [Microcella sp. MMS21-STM10]
MTTERFSQFDAADYLSDMETAAAYLEATIAESGDDPATISAALGAIARSGNLSELARRTGMSREGLYKALSADGNPSFAT
IVKVSRALGLRLEFHAIA

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References