Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 932834..933363 Replicon chromosome
Accession NZ_CP101472
Organism Staphylococcus equorum strain DX2

Toxin (Protein)


Gene name mazF Uniprot ID K7S376
Locus tag NMQ06_RS04405 Protein ID WP_002511418.1
Coordinates 933001..933363 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID J9GY23
Locus tag NMQ06_RS04400 Protein ID WP_002507108.1
Coordinates 932834..933004 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMQ06_RS04375 (NMQ06_04370) 928585..929064 + 480 WP_021339947.1 PH domain-containing protein -
NMQ06_RS04380 (NMQ06_04375) 929057..930562 + 1506 WP_021339948.1 PH domain-containing protein -
NMQ06_RS04385 (NMQ06_04380) 930555..931091 + 537 WP_002507105.1 PH domain-containing protein -
NMQ06_RS04390 (NMQ06_04385) 931124..931474 + 351 WP_021339949.1 holo-ACP synthase -
NMQ06_RS04395 (NMQ06_04390) 931598..932746 + 1149 WP_021339950.1 alanine racemase -
NMQ06_RS04400 (NMQ06_04395) 932834..933004 + 171 WP_002507108.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
NMQ06_RS04405 (NMQ06_04400) 933001..933363 + 363 WP_002511418.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NMQ06_RS04410 (NMQ06_04405) 933722..934723 + 1002 WP_002507111.1 PP2C family protein-serine/threonine phosphatase -
NMQ06_RS04415 (NMQ06_04410) 934803..935129 + 327 WP_002511417.1 anti-sigma factor antagonist -
NMQ06_RS04420 (NMQ06_04415) 935131..935613 + 483 WP_002507113.1 anti-sigma B factor RsbW -
NMQ06_RS04425 (NMQ06_04420) 935588..936358 + 771 WP_002507114.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13432.59 Da        Isoelectric Point: 10.2178

>T252154 WP_002511418.1 NZ_CP101472:933001-933363 [Staphylococcus equorum]
MMRRGDVYLADLSPVQGSEQGGIRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKSKYKLDKDSVILLEQIR
TLDKNRLKEKLTYLSESKMKEVNVAIDISLGLHNVRNSKS

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6305.92 Da        Isoelectric Point: 4.0121

>AT252154 WP_002507108.1 NZ_CP101472:932834-933004 [Staphylococcus equorum]
MASFNQSRNHSIEQLLKEGYSQMADLNLSLAAEAFPFECEACDCNEVYLSSKNNNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K7S376

Antitoxin

Source ID Structure
AlphaFold DB J9GY23

References