Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 921365..921885 Replicon chromosome
Accession NZ_CP101472
Organism Staphylococcus equorum strain DX2

Toxin (Protein)


Gene name TsdT Uniprot ID A0A192F7F2
Locus tag NMQ06_RS04345 Protein ID WP_031266142.1
Coordinates 921673..921885 (+) Length 71 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID J9GWP4
Locus tag NMQ06_RS04340 Protein ID WP_002507096.1
Coordinates 921365..921658 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMQ06_RS04315 (NMQ06_04310) 916502..917293 + 792 WP_031266140.1 hydroxyethylthiazole kinase -
NMQ06_RS04320 (NMQ06_04315) 917293..917931 + 639 WP_021339941.1 thiamine phosphate synthase -
NMQ06_RS04325 (NMQ06_04320) 918019..918888 + 870 WP_002507093.1 membrane protein insertase YidC -
NMQ06_RS04330 (NMQ06_04325) 918959..919609 - 651 WP_021339942.1 HD domain-containing protein -
NMQ06_RS04335 (NMQ06_04330) 919737..921221 - 1485 WP_021339943.1 cardiolipin synthase -
NMQ06_RS04340 (NMQ06_04335) 921365..921658 + 294 WP_002507096.1 copper-sensing transcriptional repressor CsoR Antitoxin
NMQ06_RS04345 (NMQ06_04340) 921673..921885 + 213 WP_031266142.1 heavy metal-associated domain-containing protein Toxin
NMQ06_RS04350 (NMQ06_04345) 922099..922239 + 141 WP_255157202.1 Lmo0850 family protein -
NMQ06_RS04355 (NMQ06_04350) 922395..923597 - 1203 WP_002507099.1 rod shape-determining protein RodA -
NMQ06_RS04360 (NMQ06_04355) 923872..924942 + 1071 WP_002507100.1 D-alanine--D-alanine ligase -
NMQ06_RS04365 (NMQ06_04360) 924955..926310 + 1356 WP_021339945.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(18-67)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 71 a.a.        Molecular weight: 8116.13 Da        Isoelectric Point: 4.5086

>T252153 WP_031266142.1 NZ_CP101472:921673-921885 [Staphylococcus equorum]
VVTKVIYISGIENETQQKHIEQQLKQLHGVHQVNIEIESNNGKIFIDFETPASLNNLEKEVYDLGYEILY

Download         Length: 213 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11195.87 Da        Isoelectric Point: 6.4791

>AT252153 WP_002507096.1 NZ_CP101472:921365-921658 [Staphylococcus equorum]
MAEIQKAHHSEQIKSNLKSRLNRIEGQVRAINRMVDEDVYCDDVLTQIRATRSALNGVATKLLDHHMKSCIMEKVEQGQQ
EEAMEELLVTFQKLMKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A192F7F2

Antitoxin

Source ID Structure
AlphaFold DB J9GWP4

References