Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 2435349..2436301 Replicon chromosome
Accession NZ_CP101467
Organism Rhodococcus gordoniae strain DND3

Toxin (Protein)


Gene name pezT Uniprot ID -
Locus tag NMQ04_RS11315 Protein ID WP_255161103.1
Coordinates 2435349..2435918 (-) Length 190 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID A0A379LXU0
Locus tag NMQ04_RS11320 Protein ID WP_064064056.1
Coordinates 2435915..2436301 (-) Length 129 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMQ04_RS11315 (NMQ04_11290) 2435349..2435918 - 570 WP_255161103.1 zeta toxin family protein Toxin
NMQ04_RS11320 (NMQ04_11295) 2435915..2436301 - 387 WP_064064056.1 hypothetical protein Antitoxin
NMQ04_RS11325 (NMQ04_11300) 2436506..2437576 + 1071 WP_255161105.1 class I SAM-dependent methyltransferase -
NMQ04_RS11330 (NMQ04_11305) 2437644..2438009 + 366 WP_129976890.1 HNH endonuclease -
NMQ04_RS11335 (NMQ04_11310) 2439460..2439678 + 219 WP_016934994.1 hypothetical protein -
NMQ04_RS11340 (NMQ04_11315) 2439766..2440257 + 492 WP_064064053.1 redox-sensitive transcriptional activator SoxR -
NMQ04_RS11345 (NMQ04_11320) 2440270..2441154 - 885 WP_255161106.1 alpha/beta fold hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-136)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(7-70)


Sequences

Toxin        


Download         Length: 190 a.a.        Molecular weight: 20550.75 Da        Isoelectric Point: 9.9259

>T252151 WP_255161103.1 NZ_CP101467:c2435918-2435349 [Rhodococcus gordoniae]
MRRLDLIVGPNGSGKSTFVELSLAPLLPHSVFVNADVIARQRWPERAEEMSYEAAQLAAAARDRLMRQGRSFIAETVFSH
PSKLELVDRAHEAGYVVVLHVMLVPETMSVLRVQHRVAAGGHAVPEDKIRARYRRLWPLVVEAIGRADQASVYDTASGTP
VVVARFAGGVPVGAVSWPVWAPAVLTGLG

Download         Length: 570 bp

Antitoxin


Download         Length: 129 a.a.        Molecular weight: 13934.39 Da        Isoelectric Point: 4.8265

>AT252151 WP_064064056.1 NZ_CP101467:c2436301-2435915 [Rhodococcus gordoniae]
MTSSTDKVTRFDAELVDSAIAEGGRQNRTGRQQLEYWARIGRAMTAHETASLHRVHEALAGTREPEDLTAAEGRLFDAEI
DARLADGLARTDYAEVLAARGVTTVVLDDAGRLVEQRPDGSRRVLGDA

Download         Length: 387 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A379LXU0

References