Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-YefM
Location 1675933..1676448 Replicon chromosome
Accession NZ_CP101465
Organism Micrococcus luteus strain DNA1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag NMQ02_RS07665 Protein ID WP_049159304.1
Coordinates 1675933..1676187 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID D3LMN2
Locus tag NMQ02_RS07670 Protein ID WP_002855277.1
Coordinates 1676188..1676448 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMQ02_RS07635 (NMQ02_07640) 1671452..1672858 + 1407 WP_255166482.1 Dyp-type peroxidase -
NMQ02_RS07640 (NMQ02_07645) 1672855..1673244 + 390 WP_255166484.1 hypothetical protein -
NMQ02_RS07645 (NMQ02_07650) 1673275..1674000 + 726 WP_255166486.1 histidine phosphatase family protein -
NMQ02_RS07650 (NMQ02_07655) 1673997..1674539 + 543 WP_248124040.1 DUF3090 domain-containing protein -
NMQ02_RS07655 (NMQ02_07660) 1674539..1675321 + 783 WP_255166490.1 SCO1664 family protein -
NMQ02_RS07660 (NMQ02_07665) 1675365..1675931 - 567 WP_255166492.1 mismatch-specific DNA-glycosylase -
NMQ02_RS07665 (NMQ02_07670) 1675933..1676187 - 255 WP_049159304.1 Txe/YoeB family addiction module toxin Toxin
NMQ02_RS07670 (NMQ02_07675) 1676188..1676448 - 261 WP_002855277.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
NMQ02_RS07675 (NMQ02_07680) 1676784..1678009 + 1226 WP_255166495.1 IS3 family transposase -
NMQ02_RS07680 (NMQ02_07685) 1678079..1678994 + 916 WP_255166497.1 IS5 family transposase -
NMQ02_RS07685 (NMQ02_07690) 1679129..1679497 + 369 Protein_1485 FAD-binding oxidoreductase -
NMQ02_RS07690 (NMQ02_07695) 1679694..1680936 + 1243 WP_255166499.1 IS3 family transposase -
NMQ02_RS07695 (NMQ02_07700) 1680964..1681095 - 132 Protein_1487 four-helix bundle copper-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-70)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9984.32 Da        Isoelectric Point: 7.3151

>T252150 WP_049159304.1 NZ_CP101465:c1676187-1675933 [Micrococcus luteus]
VRLVWDRSAWEDYTHWQTTDRKVLKRINTLIDAALRDPFEGIGKPEQLKYGAAGAWSRRITEEHRLVYLVDGEDLIILQA
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9579.71 Da        Isoelectric Point: 4.8359

>AT252150 WP_002855277.1 NZ_CP101465:c1676448-1676188 [Micrococcus luteus]
MSISASEARKTLFPLIERVNADRDAVEIVSRKGNAVLMPADEYAAWQETAYLFRSPANARRLLDAYERARAGSVEEHALD
RLDGDA

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A031HW70

References