Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2330219..2330764 Replicon chromosome
Accession NC_015460
Organism Gallibacterium anatis UMN179

Toxin (Protein)


Gene name relE Uniprot ID F4HF99
Locus tag UMN179_RS10915 Protein ID WP_013746939.1
Coordinates 2330477..2330764 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0A3A4K2
Locus tag UMN179_RS10910 Protein ID WP_039083793.1
Coordinates 2330219..2330467 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
UMN179_RS10895 2326067..2327194 + 1128 WP_013746935.1 porin -
UMN179_RS12965 2327374..2327562 - 189 WP_080558809.1 hypothetical protein -
UMN179_RS10900 2328495..2329640 + 1146 WP_013746936.1 porin -
UMN179_RS10905 2329782..2330042 + 261 WP_013746937.1 DUF1778 domain-containing protein -
UMN179_RS10910 2330219..2330467 + 249 WP_039083793.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
UMN179_RS10915 2330477..2330764 + 288 WP_013746939.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
UMN179_RS10920 2331078..2331680 - 603 WP_013744975.1 hypothetical protein -
UMN179_RS10925 2332035..2332397 - 363 WP_013746940.1 type II toxin-antitoxin system PemK/MazF family toxin -
UMN179_RS10930 2332397..2332663 - 267 WP_013746941.1 antitoxin MazE -
UMN179_RS10935 2332867..2334882 - 2016 WP_013746942.1 NAD-dependent DNA ligase LigA -
UMN179_RS13220 2334967..2335134 - 168 WP_013746943.1 DUF5363 family protein -
UMN179_RS10940 2335156..2335647 - 492 WP_013746944.1 YajQ family cyclic di-GMP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-66)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11026.94 Da        Isoelectric Point: 10.4262

>T25215 WP_013746939.1 NC_015460:2330477-2330764 [Gallibacterium anatis UMN179]
MAYAIKVHSDFVAELNKLDSTIKNQLRKKLEKVVHNPHIPKNRLSGELHNCYKIKLRKAGVRLVYQVNDDEIYILLLTVG
KREAKQVYNTALNRV

Download         Length: 288 bp

>T25215 NC_015460:2330477-2330764 [Gallibacterium anatis UMN179]
ATGGCTTATGCAATTAAGGTGCATAGTGATTTTGTGGCAGAATTGAATAAATTAGATTCTACTATAAAAAATCAGCTACG
AAAGAAATTGGAAAAAGTAGTACACAATCCACATATTCCTAAAAATAGATTAAGTGGAGAGCTTCATAATTGTTATAAAA
TTAAACTAAGAAAAGCTGGAGTGCGGTTGGTTTACCAAGTCAATGATGATGAAATTTATATCTTATTACTGACAGTTGGT
AAGCGAGAGGCTAAGCAAGTTTATAACACTGCATTAAATCGAGTTTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9375.72 Da        Isoelectric Point: 4.4230

>AT25215 WP_039083793.1 NC_015460:2330219-2330467 [Gallibacterium anatis UMN179]
MANLNIRIDDTIKQRAFLAFDNLGINPSEAIRTFLTYVADTGRMPIKQIIVSDEDTELYEVVKKRLNEPEKITATTLDEL
FS

Download         Length: 249 bp

>AT25215 NC_015460:2330219-2330467 [Gallibacterium anatis UMN179]
ATGGCTAATTTAAATATTCGTATTGATGATACTATTAAACAGAGGGCATTTTTAGCTTTTGATAATTTAGGCATTAATCC
ATCGGAAGCAATCCGTACATTTTTGACCTATGTCGCAGACACAGGGAGGATGCCAATTAAACAAATTATTGTCTCGGATG
AAGACACTGAGCTTTATGAGGTAGTGAAAAAACGCTTAAATGAACCGGAGAAAATCACTGCAACTACATTGGATGAGCTT
TTCTCTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB F4HF99

Antitoxin

Source ID Structure
AlphaFold DB A0A0A3A4K2

References