Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) rlegTA/AbiEii-AbiEi
Location 4631214..4632679 Replicon chromosome
Accession NZ_CP101417
Organism Xanthomonas hortorum strain jj2001

Toxin (Protein)


Gene name rlegT Uniprot ID V7ZC16
Locus tag NMB96_RS19750 Protein ID WP_023904377.1
Coordinates 4631816..4632679 (+) Length 288 a.a.

Antitoxin (Protein)


Gene name rlegA Uniprot ID V7ZCN1
Locus tag NMB96_RS19745 Protein ID WP_023904376.1
Coordinates 4631214..4631819 (+) Length 202 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMB96_RS19710 (NMB96_19695) 4626307..4626888 - 582 WP_043889282.1 hypothetical protein -
NMB96_RS19715 (NMB96_19700) 4627148..4628128 + 981 WP_183086603.1 IS5 family transposase -
NMB96_RS19720 (NMB96_19705) 4628244..4628510 - 267 WP_043889283.1 hypothetical protein -
NMB96_RS19725 (NMB96_19710) 4628639..4628842 - 204 WP_023904372.1 hypothetical protein -
NMB96_RS19730 (NMB96_19715) 4628863..4629111 - 249 WP_023904373.1 hypothetical protein -
NMB96_RS19735 (NMB96_19720) 4629128..4630336 - 1209 WP_023904374.1 XRE family transcriptional regulator -
NMB96_RS19740 (NMB96_19725) 4630333..4630989 - 657 WP_023904375.1 hypothetical protein -
NMB96_RS19745 (NMB96_19730) 4631214..4631819 + 606 WP_023904376.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
NMB96_RS19750 (NMB96_19735) 4631816..4632679 + 864 WP_023904377.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
NMB96_RS19755 (NMB96_19740) 4632945..4633708 + 764 WP_095574585.1 IS5 family transposase -
NMB96_RS19760 (NMB96_19745) 4633838..4634096 - 259 Protein_3862 DDE-type integrase/transposase/recombinase -
NMB96_RS19770 (NMB96_19755) 4634920..4635456 + 537 WP_023904378.1 lipocalin family protein -
NMB96_RS19775 (NMB96_19760) 4635571..4636047 + 477 WP_023904379.1 LEA type 2 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 4627148..4633708 6560


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(38-261)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(8-55)


Sequences

Toxin        


Download         Length: 288 a.a.        Molecular weight: 31435.36 Da        Isoelectric Point: 6.3504

>T252146 WP_023904377.1 NZ_CP101417:4631816-4632679 [Xanthomonas hortorum]
MSAATPNVAASVRARLLNVAKAQGVDFNQVLVRFALERILYRLTKSPHADRFLLKGALLFTLWYDMPHRATRDADLLGFG
ASDLESVAQVFWDIAAVPVDDGIVFDPASVTVEEIRKEAGYGGVRVMIAGDLARARCKTQIDVGFGDAVTPAPVDSVYPV
LLEEMPAPRLRAYPTYTVVAEKLHAIALLGMTNSRLKDYFDLSVLLKRETLDTDLLAQAINATFERRGMVVPDALPVGLT
DEFAHDASRQALWLAFLKKNELPQEPLHAIVGRLSVALTPALNTVAR

Download         Length: 864 bp

Antitoxin


Download         Length: 202 a.a.        Molecular weight: 22257.77 Da        Isoelectric Point: 9.6997

>AT252146 WP_023904376.1 NZ_CP101417:4631214-4631819 [Xanthomonas hortorum]
MLSSTHNQRVLDLASQKGLLRASDLEAISAPRVVLTRMTAAGLLEKVGRGLYRLPDAQISEFESLGTIATKAPQAVFCLL
TALQFHELTTELPRQIWIAMPRGSHPPRVDYPPVKLVQFTGDAYSAGIDEVERDGVRLRVYSAAKTVADCFKHRNKIGLD
VALEALKDARARNKASVDDIWRFAKICRVANVMRPYLESVG

Download         Length: 606 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6V7D7M5

Antitoxin

Source ID Structure
AlphaFold DB A0A6V7D9G3

References