Detailed information of TA system TA025214

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 2287134..2287683
• Replicon: chromosome
• Accession: NC_015460
• Organism: Gallibacterium anatis UMN179

Toxin (Protein)

• Gene name: relE
• Uniprot ID: F4HEY3
• Locus tag: UMN179_RS10725
• Protein ID: WP_013746900.1
• Coordinates: 2287134..2287433 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: F4HEY4
• Locus tag: UMN179_RS10730
• Protein ID: WP_013746901.1
• Coordinates: 2287423..2287683 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
UMN179_RS10705	2283580..2284689	+	1110	WP_039085718.1	Fic family protein	-
UMN179_RS10710	2284754..2285494	-	741	WP_013746897.1	glycosyltransferase family 25 protein	-
UMN179_RS10715	2285495..2286724	-	1230	WP_013746898.1	O-antigen ligase family protein	-
UMN179_RS10720	2286791..2287009	-	219	WP_013746899.1	translation initiation factor IF-1	-
UMN179_RS10725	2287134..2287433	-	300	WP_013746900.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
UMN179_RS10730	2287423..2287683	-	261	WP_013746901.1	stability protein StbD	Antitoxin
UMN179_RS10735	2287955..2289517	+	1563	WP_013746902.1	Fic family protein	-
UMN179_RS10740	2289630..2290754	+	1125	WP_039088712.1	LPS O-antigen chain length determinant protein WzzB	-
UMN179_RS10745	2290771..2291577	+	807	WP_013746904.1	DUF4422 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2281911..2283344	1433

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-85)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11752.61 Da
• Isoelectric Point: 10.4596

>T25214 WP_013746900.1 NC_015460:c2287433-2287134 [Gallibacterium anatis UMN179]
MTYSLQFHEKALKEWKKLDETTRSQLKKKLAERLQNPHIQADRLSGFSNPTYKIKLRSIGYRLVYEVNDDIITVFVLSVG
KRNKLQAYINAHHRAEKMY

Nucleotide

• Length: 300 bp

>T25214 NC_015460:c2287433-2287134 [Gallibacterium anatis UMN179]
ATGACTTATAGCCTACAGTTTCACGAAAAAGCACTTAAAGAGTGGAAAAAACTAGATGAAACAACGAGAAGTCAATTAAA
AAAGAAACTTGCTGAACGCCTCCAAAATCCACATATTCAAGCTGATAGATTAAGTGGATTTTCTAATCCAACCTATAAGA
TTAAATTACGTTCTATCGGATATCGTCTTGTGTATGAGGTGAATGACGATATTATCACTGTTTTTGTGCTTTCTGTAGGA
AAGCGAAATAAATTGCAAGCCTACATCAATGCTCACCACAGGGCAGAAAAAATGTATTAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9829.28 Da
• Isoelectric Point: 6.2191

>AT25214 WP_013746901.1 NC_015460:c2287683-2287423 [Gallibacterium anatis UMN179]
MKNVHKIHTDVVASITSLKRDPMGTIYNDTGSQAVAILNRNQPAFYCITPELFEHFLELEENAELAKIVQERKKEGKFIK
VNIDDL

Nucleotide

• Length: 261 bp

>AT25214 NC_015460:c2287683-2287423 [Gallibacterium anatis UMN179]
ATGAAAAATGTTCATAAAATACATACTGATGTTGTTGCCAGTATTACCTCGTTAAAACGCGACCCAATGGGAACGATTTA
TAACGATACCGGTAGTCAAGCTGTTGCTATTCTCAACCGTAATCAACCTGCATTTTATTGTATTACGCCTGAACTCTTTG
AGCATTTTCTAGAATTAGAAGAAAATGCTGAATTGGCAAAAATAGTGCAAGAACGCAAAAAAGAAGGGAAATTTATTAAG
GTGAATATTGATGACTTATAG

Structures

Toxin

• AlphaFold DB: F4HEY3

Antitoxin

• AlphaFold DB: F4HEY4