Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 83826..85449 Replicon plasmid pSC2017297-mcr-249k
Accession NZ_CP101391
Organism Salmonella enterica strain SC2017297

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag NMU39_RS24835 Protein ID WP_000088046.1
Coordinates 84124..85449 (+) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag NMU39_RS24830 Protein ID WP_024136327.1
Coordinates 83826..84119 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU39_RS24800 (NMU39_24795) 79698..80939 + 1242 WP_001053338.1 VWA domain-containing protein -
NMU39_RS24805 81030..81161 + 132 WP_000374059.1 hypothetical protein -
NMU39_RS24810 (NMU39_24800) 81502..81783 - 282 WP_000077926.1 hypothetical protein -
NMU39_RS24815 (NMU39_24805) 81833..82024 - 192 WP_000398480.1 hypothetical protein -
NMU39_RS24820 (NMU39_24810) 82116..82457 - 342 WP_001151575.1 hypothetical protein -
NMU39_RS24825 (NMU39_24815) 82830..83222 + 393 WP_000341066.1 hypothetical protein -
NMU39_RS24830 (NMU39_24820) 83826..84119 + 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
NMU39_RS24835 (NMU39_24825) 84124..85449 + 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
NMU39_RS24840 (NMU39_24830) 85510..85716 + 207 WP_000134171.1 hypothetical protein -
NMU39_RS24845 (NMU39_24835) 85818..86228 + 411 WP_000985911.1 hypothetical protein -
NMU39_RS24850 (NMU39_24840) 86241..87056 + 816 WP_001572439.1 HNH endonuclease signature motif containing protein -
NMU39_RS24855 (NMU39_24845) 87310..87735 + 426 WP_001043843.1 hypothetical protein -
NMU39_RS24860 (NMU39_24850) 88189..88425 + 237 Protein_86 type I restriction-modification system subunit M N-terminal domain-containing protein -
NMU39_RS24865 (NMU39_24855) 88480..88779 + 300 WP_001572440.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid mcr-1.1 / blaCTX-M-14 / fosA3 / aac(3)-IVa / sul2 / floR / aadA2 / cmlA1 / ant(3'')-Ia / sul3 / aph(3')-Ia / sul1 / oqxA / oqxB - 1..249573 249573


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50249.20 Da        Isoelectric Point: 6.1927

>T252132 WP_000088046.1 NZ_CP101391:84124-85449 [Salmonella enterica]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10946.35 Da        Isoelectric Point: 10.0925

>AT252132 WP_024136327.1 NZ_CP101391:83826-84119 [Salmonella enterica]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References