Detailed information of TA system TA025213

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2276584..2277221
• Replicon: chromosome
• Accession: NC_015460
• Organism: Gallibacterium anatis UMN179

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: UMN179_RS10680
• Protein ID: WP_013746891.1
• Coordinates: 2276814..2277221 (+)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: UMN179_RS10675
• Protein ID: WP_172459775.1
• Coordinates: 2276584..2276814 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
UMN179_RS10655	2271992..2273002	-	1011	WP_013746886.1	biotin synthase BioB	-
UMN179_RS10660	2273042..2273704	-	663	WP_013746887.1	thiamine ABC transporter ATP-binding protein	-
UMN179_RS10665	2273691..2275313	-	1623	WP_013746888.1	thiamine/thiamine pyrophosphate ABC transporter permease	-
UMN179_RS10670	2275289..2276284	-	996	WP_013746889.1	thiamine ABC transporter substrate binding subunit	-
UMN179_RS10675	2276584..2276814	+	231	WP_172459775.1	antitoxin	Antitoxin
UMN179_RS10680	2276814..2277221	+	408	WP_013746891.1	tRNA(fMet)-specific endonuclease VapC	Toxin
UMN179_RS10685	2277321..2278325	-	1005	WP_013746892.1	16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC	-
UMN179_RS10690	2278410..2280455	-	2046	WP_043885288.1	methionine--tRNA ligase	-
UMN179_RS10695	2280653..2281771	+	1119	WP_013746894.1	iron-sulfur cluster carrier protein ApbC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2281911..2283344	1433

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 14934.44 Da
• Isoelectric Point: 7.8732

>T25213 WP_013746891.1 NC_015460:2276814-2277221 [Gallibacterium anatis UMN179]
MLKYMLDTNIVIFTIKNKPSHLLPLFNENQSMLCISSITLMELVYGAEKSKKTAQNLAVIESFCARLAVLDYGEAAAYHS
GQIRAELAKIGQPIGPYDAMIAGHARSLGLTVVTNNMNEFSRVEGVRVIDWSKPM

Nucleotide

• Length: 408 bp

>T25213 NC_015460:2276814-2277221 [Gallibacterium anatis UMN179]
ATGCTGAAATATATGTTGGATACCAATATCGTTATATTTACGATAAAAAATAAGCCGTCACATTTGTTGCCGTTATTTAA
TGAAAATCAATCTATGCTTTGTATCAGCTCGATTACATTAATGGAGCTGGTTTATGGGGCAGAGAAAAGCAAAAAAACGG
CACAGAATCTTGCCGTTATCGAATCTTTCTGTGCAAGATTAGCCGTTTTGGATTATGGTGAGGCAGCAGCATATCATAGT
GGGCAGATAAGAGCTGAATTAGCAAAAATTGGGCAACCTATTGGACCATATGACGCAATGATCGCCGGGCACGCAAGGAG
TCTAGGCTTGACAGTTGTTACTAACAATATGAATGAGTTTTCACGGGTAGAGGGGGTAAGAGTAATCGATTGGAGTAAGC
CGATGTAA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8707.81 Da
• Isoelectric Point: 4.4013

>AT25213 WP_172459775.1 NC_015460:2276584-2276814 [Gallibacterium anatis UMN179]
VTATVFMNNKSQAIRIPKAAELPNTTKSVNIIIQGDMRIITPLNNVWDSWFNDSNSVSDDFMLSREQPQIQEREEL

Nucleotide

• Length: 231 bp

>AT25213 NC_015460:2276584-2276814 [Gallibacterium anatis UMN179]
GTGACCGCAACTGTTTTTATGAATAATAAAAGCCAAGCTATCAGAATTCCGAAAGCTGCAGAATTACCTAATACTACAAA
AAGTGTAAATATTATTATTCAAGGGGATATGCGTATTATCACACCTCTCAATAATGTTTGGGACAGCTGGTTCAATGATT
CAAATTCCGTATCGGACGATTTTATGTTAAGTCGTGAGCAACCACAGATACAGGAAAGGGAAGAATTATAA