Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4419158..4419939 Replicon chromosome
Accession NZ_CP101390
Organism Salmonella enterica strain SC2017297

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag NMU39_RS21715 Protein ID WP_000626099.1
Coordinates 4419158..4419649 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag NMU39_RS21720 Protein ID WP_001110452.1
Coordinates 4419646..4419939 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU39_RS21680 (4415153) 4415153..4415728 + 576 WP_001188509.1 transcriptional regulator -
NMU39_RS21690 (4415999) 4415999..4416076 - 78 Protein_4242 helix-turn-helix domain-containing protein -
NMU39_RS21695 (4416167) 4416167..4416499 - 333 WP_001165471.1 MerR family transcriptional regulator -
NMU39_RS21700 (4416571) 4416571..4416948 + 378 WP_000916345.1 EthD family reductase -
NMU39_RS21705 (4417981) 4417981..4418055 + 75 Protein_4245 porin family protein -
NMU39_RS21710 (4418158) 4418158..4418910 + 753 WP_000842434.1 non-specific acid phosphatase -
NMU39_RS21715 (4419158) 4419158..4419649 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
NMU39_RS21720 (4419646) 4419646..4419939 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
NMU39_RS21725 (4420256) 4420256..4420477 + 222 WP_001576552.1 hypothetical protein -
NMU39_RS21730 (4420742) 4420742..4421617 + 876 WP_000921674.1 AraC family transcriptional regulator -
NMU39_RS21735 (4421614) 4421614..4421901 + 288 WP_001269916.1 transcriptional regulator RtsB -
NMU39_RS21740 (4421924) 4421924..4422139 + 216 WP_001595136.1 hypothetical protein -
NMU39_RS21745 (4422147) 4422147..4422416 + 270 WP_010989096.1 hypothetical protein -
NMU39_RS21750 (4422710) 4422710..4423615 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T252129 WP_000626099.1 NZ_CP101390:c4419649-4419158 [Salmonella enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT252129 WP_001110452.1 NZ_CP101390:c4419939-4419646 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References