252128

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4289821..4290337 Replicon chromosome
Accession NZ_CP101390
Organism Salmonella enterica strain SC2017297

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag NMU39_RS21040 Protein ID WP_000220578.1
Coordinates 4289821..4290105 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag NMU39_RS21045 Protein ID WP_000212724.1
Coordinates 4290095..4290337 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU39_RS21025 (4285033) 4285033..4286685 + 1653 WP_000155057.1 alpha,alpha-phosphotrehalase -
NMU39_RS21030 (4287094) 4287094..4289232 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
NMU39_RS21035 (4289353) 4289353..4289817 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NMU39_RS21040 (4289821) 4289821..4290105 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NMU39_RS21045 (4290095) 4290095..4290337 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NMU39_RS21050 (4290415) 4290415..4292328 - 1914 WP_001212137.1 BglG family transcription antiterminator -
NMU39_RS21055 (4292345) 4292345..4293085 - 741 WP_000779263.1 KDGP aldolase family protein -
NMU39_RS21060 (4293082) 4293082..4294200 - 1119 WP_001139182.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
NMU39_RS21065 (4294184) 4294184..4295317 - 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T252128 WP_000220578.1 NZ_CP101390:c4290105-4289821 [Salmonella enterica]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT252128 WP_000212724.1 NZ_CP101390:c4290337-4290095 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References