Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3576643..3577263 Replicon chromosome
Accession NZ_CP101390
Organism Salmonella enterica strain SC2017297

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NMU39_RS17765 Protein ID WP_001280991.1
Coordinates 3577045..3577263 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag NMU39_RS17760 Protein ID WP_000344807.1
Coordinates 3576643..3577017 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU39_RS17750 (3571782) 3571782..3572975 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NMU39_RS17755 (3572998) 3572998..3576147 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
NMU39_RS17760 (3576643) 3576643..3577017 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
NMU39_RS17765 (3577045) 3577045..3577263 + 219 WP_001280991.1 HHA domain-containing protein Toxin
NMU39_RS17770 (3577442) 3577442..3577993 + 552 WP_001278792.1 maltose O-acetyltransferase -
NMU39_RS17775 (3578110) 3578110..3578580 + 471 WP_000136181.1 YlaC family protein -
NMU39_RS17780 (3578636) 3578636..3578776 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
NMU39_RS17785 (3578782) 3578782..3579042 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
NMU39_RS17790 (3579267) 3579267..3580817 + 1551 WP_000213139.1 EAL domain-containing protein -
NMU39_RS17800 (3581048) 3581048..3581437 + 390 WP_000961285.1 MGMT family protein -
NMU39_RS17805 (3581470) 3581470..3582039 - 570 WP_000779803.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T252124 WP_001280991.1 NZ_CP101390:3577045-3577263 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT252124 WP_000344807.1 NZ_CP101390:3576643-3577017 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References