Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 951036..951696 Replicon chromosome
Accession NZ_CP101390
Organism Salmonella enterica strain SC2017297

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag NMU39_RS04660 Protein ID WP_000244756.1
Coordinates 951283..951696 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag NMU39_RS04655 Protein ID WP_000351186.1
Coordinates 951036..951302 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU39_RS04635 (946964) 946964..948397 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
NMU39_RS04640 (948556) 948556..948867 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
NMU39_RS04645 (949031) 949031..949690 + 660 WP_000250289.1 hemolysin III family protein -
NMU39_RS04650 (949806) 949806..950786 - 981 WP_000874172.1 tRNA-modifying protein YgfZ -
NMU39_RS04655 (951036) 951036..951302 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
NMU39_RS04660 (951283) 951283..951696 + 414 WP_000244756.1 protein YgfX Toxin
NMU39_RS04665 (951749) 951749..952270 - 522 WP_001055885.1 flavodoxin FldB -
NMU39_RS04670 (952383) 952383..953279 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
NMU39_RS04675 (953303) 953303..954016 + 714 WP_000745625.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NMU39_RS04680 (954022) 954022..955755 + 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T252116 WP_000244756.1 NZ_CP101390:951283-951696 [Salmonella enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT252116 WP_000351186.1 NZ_CP101390:951036-951302 [Salmonella enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References