Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 86690..88313 Replicon plasmid pSC2017167-mcr-256k
Accession NZ_CP101389
Organism Salmonella enterica strain SC2017167

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag NMU38_RS24960 Protein ID WP_000088046.1
Coordinates 86988..88313 (+) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag NMU38_RS24955 Protein ID WP_024136327.1
Coordinates 86690..86983 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU38_RS24925 (NMU38_24920) 82562..83803 + 1242 WP_001053338.1 VWA domain-containing protein -
NMU38_RS24930 83894..84025 + 132 WP_000374059.1 hypothetical protein -
NMU38_RS24935 (NMU38_24925) 84366..84647 - 282 WP_000077926.1 hypothetical protein -
NMU38_RS24940 (NMU38_24930) 84697..84888 - 192 WP_000398480.1 hypothetical protein -
NMU38_RS24945 (NMU38_24935) 84980..85321 - 342 WP_001151575.1 hypothetical protein -
NMU38_RS24950 (NMU38_24940) 85694..86086 + 393 WP_000341066.1 hypothetical protein -
NMU38_RS24955 (NMU38_24945) 86690..86983 + 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
NMU38_RS24960 (NMU38_24950) 86988..88313 + 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
NMU38_RS24965 (NMU38_24955) 88374..88580 + 207 WP_000134171.1 hypothetical protein -
NMU38_RS24970 (NMU38_24960) 88682..89092 + 411 WP_000985911.1 hypothetical protein -
NMU38_RS24975 (NMU38_24965) 89105..89920 + 816 WP_053276223.1 HNH endonuclease signature motif containing protein -
NMU38_RS24980 (NMU38_24970) 90174..90599 + 426 WP_001043843.1 hypothetical protein -
NMU38_RS24985 (NMU38_24975) 91148..91456 + 309 WP_001224687.1 hypothetical protein -
NMU38_RS24990 (NMU38_24980) 91472..92329 + 858 WP_000784387.1 HNH endonuclease signature motif containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid mcr-1.1 / sul2 / floR / mph(A) / aac(3)-IVa / fosA3 / blaCTX-M-14 / dfrA12 / aadA2 / cmlA1 / ant(3'')-Ia / sul3 / aph(3')-Ia / sul1 / oqxA / oqxB - 1..256591 256591


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50249.20 Da        Isoelectric Point: 6.1927

>T252112 WP_000088046.1 NZ_CP101389:86988-88313 [Salmonella enterica]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10946.35 Da        Isoelectric Point: 10.0925

>AT252112 WP_024136327.1 NZ_CP101389:86690-86983 [Salmonella enterica]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References