Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1689998..1690615 Replicon chromosome
Accession NC_015460
Organism Gallibacterium anatis UMN179

Toxin (Protein)


Gene name hicA Uniprot ID A0A0A2Y920
Locus tag UMN179_RS07935 Protein ID WP_039133250.1
Coordinates 1690433..1690615 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID F4HBU2
Locus tag UMN179_RS07930 Protein ID WP_013746351.1
Coordinates 1689998..1690405 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
UMN179_RS07910 1685830..1686747 - 918 WP_202795520.1 restriction endonuclease -
UMN179_RS07915 1687386..1687568 + 183 WP_013746348.1 glycine zipper 2TM domain-containing protein -
UMN179_RS07920 1687684..1688271 - 588 WP_202795525.1 uracil-DNA glycosylase family protein -
UMN179_RS07925 1688352..1689464 - 1113 WP_013746350.1 aspartate-semialdehyde dehydrogenase -
UMN179_RS12910 1689759..1689983 + 225 WP_080558802.1 ogr/Delta-like zinc finger family protein -
UMN179_RS07930 1689998..1690405 - 408 WP_013746351.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
UMN179_RS07935 1690433..1690615 - 183 WP_039133250.1 type II toxin-antitoxin system HicA family toxin Toxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6830.10 Da        Isoelectric Point: 10.8973

>T25211 WP_039133250.1 NC_015460:c1690615-1690433 [Gallibacterium anatis UMN179]
VDSKTLIKMLEKDGWYLVNVVGSHHQFKHPIKKGRTTVPHPKKDLQIKTVNSILKQAGLK

Download         Length: 183 bp

>T25211 NC_015460:c1690615-1690433 [Gallibacterium anatis UMN179]
GTGGATAGTAAAACATTAATAAAAATGCTTGAAAAAGATGGGTGGTACTTGGTGAATGTGGTTGGTAGTCATCATCAATT
TAAACATCCAATAAAGAAAGGGCGGACAACAGTTCCGCATCCCAAAAAGGATTTACAAATAAAAACGGTAAATTCAATAT
TAAAACAAGCGGGCTTGAAATAA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14869.04 Da        Isoelectric Point: 4.4474

>AT25211 WP_013746351.1 NC_015460:c1690405-1689998 [Gallibacterium anatis UMN179]
MLYPIGIEMGDDKHAFGVIVPDVPGCFSAGDTLEEAYINAKEAIAFHIEGMLEDGEEFPLPTDIKAHMNNKEFEGFTFTF
VDVDLSHLMGKAEKINITLPALLLHKIDAFIATHPEYKSRSGFLAQLATDKLLSA

Download         Length: 408 bp

>AT25211 NC_015460:c1690405-1689998 [Gallibacterium anatis UMN179]
ATGTTATATCCGATTGGAATTGAAATGGGTGATGATAAACACGCTTTTGGGGTAATTGTGCCTGATGTGCCAGGTTGTTT
TTCTGCTGGAGATACATTAGAAGAGGCGTATATTAATGCAAAAGAAGCTATCGCTTTTCATATCGAGGGAATGTTAGAAG
ATGGTGAAGAGTTTCCTTTGCCAACCGATATAAAAGCACATATGAATAATAAAGAGTTTGAGGGGTTTACTTTTACTTTT
GTAGATGTTGATTTGTCGCATTTAATGGGTAAAGCGGAAAAAATTAATATTACTCTACCAGCGTTGTTATTACATAAAAT
TGATGCGTTTATTGCAACACATCCAGAGTATAAAAGCCGTAGTGGTTTTTTGGCACAACTTGCAACAGATAAATTACTTT
CAGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A2Y920

Antitoxin

Source ID Structure
AlphaFold DB F4HBU2

References