Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4444258..4445039 Replicon chromosome
Accession NZ_CP101388
Organism Salmonella enterica strain SC2017167

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag NMU38_RS21835 Protein ID WP_000626099.1
Coordinates 4444258..4444749 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag NMU38_RS21840 Protein ID WP_001110452.1
Coordinates 4444746..4445039 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU38_RS21795 (4439444) 4439444..4439686 - 243 WP_197603740.1 hypothetical protein -
NMU38_RS21800 (4439683) 4439683..4440039 - 357 WP_033567083.1 hypothetical protein -
NMU38_RS21805 (4440036) 4440036..4440908 - 873 WP_033567082.1 ParA family protein -
NMU38_RS21810 (4441099) 4441099..4441176 - 78 Protein_4266 helix-turn-helix domain-containing protein -
NMU38_RS21815 (4441267) 4441267..4441599 - 333 WP_001165471.1 MerR family transcriptional regulator -
NMU38_RS21820 (4441671) 4441671..4442048 + 378 WP_000916345.1 EthD family reductase -
NMU38_RS21825 (4443081) 4443081..4443155 + 75 Protein_4269 porin family protein -
NMU38_RS21830 (4443258) 4443258..4444010 + 753 WP_000842434.1 non-specific acid phosphatase -
NMU38_RS21835 (4444258) 4444258..4444749 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
NMU38_RS21840 (4444746) 4444746..4445039 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
NMU38_RS21845 (4445356) 4445356..4445577 + 222 WP_001576552.1 hypothetical protein -
NMU38_RS21850 (4445842) 4445842..4446717 + 876 WP_000921674.1 AraC family transcriptional regulator -
NMU38_RS21855 (4446714) 4446714..4447001 + 288 WP_001269916.1 transcriptional regulator RtsB -
NMU38_RS21860 (4447024) 4447024..4447239 + 216 WP_001595136.1 hypothetical protein -
NMU38_RS21865 (4447247) 4447247..4447516 + 270 WP_010989096.1 hypothetical protein -
NMU38_RS21870 (4447810) 4447810..4448715 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T252109 WP_000626099.1 NZ_CP101388:c4444749-4444258 [Salmonella enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT252109 WP_001110452.1 NZ_CP101388:c4445039-4444746 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References