Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3519664..3520284 Replicon chromosome
Accession NZ_CP101388
Organism Salmonella enterica strain SC2017167

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NMU38_RS17445 Protein ID WP_001280991.1
Coordinates 3520066..3520284 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag NMU38_RS17440 Protein ID WP_000344807.1
Coordinates 3519664..3520038 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU38_RS17430 (3514803) 3514803..3515996 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NMU38_RS17435 (3516019) 3516019..3519168 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
NMU38_RS17440 (3519664) 3519664..3520038 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
NMU38_RS17445 (3520066) 3520066..3520284 + 219 WP_001280991.1 HHA domain-containing protein Toxin
NMU38_RS17450 (3520463) 3520463..3521014 + 552 WP_001278792.1 maltose O-acetyltransferase -
NMU38_RS17455 (3521131) 3521131..3521601 + 471 WP_000136181.1 YlaC family protein -
NMU38_RS17460 (3521657) 3521657..3521797 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
NMU38_RS17465 (3521803) 3521803..3522063 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
NMU38_RS17470 (3522288) 3522288..3523838 + 1551 WP_000213139.1 EAL domain-containing protein -
NMU38_RS17480 (3524069) 3524069..3524458 + 390 WP_000961285.1 MGMT family protein -
NMU38_RS17485 (3524491) 3524491..3525060 - 570 WP_000779803.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T252104 WP_001280991.1 NZ_CP101388:3520066-3520284 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT252104 WP_000344807.1 NZ_CP101388:3519664-3520038 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References