Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 87764..89387 Replicon plasmid pSC2017100-mcr-218k
Accession NZ_CP101387
Organism Salmonella enterica strain SC2017100

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag NMU37_RS24810 Protein ID WP_000088046.1
Coordinates 88062..89387 (+) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag NMU37_RS24805 Protein ID WP_024136327.1
Coordinates 87764..88057 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU37_RS24780 (NMU37_24775) 84032..85006 - 975 WP_012478345.1 IS30-like element ISApl1 family transposase -
NMU37_RS24785 (NMU37_24780) 85440..85721 - 282 WP_000077926.1 hypothetical protein -
NMU37_RS24790 (NMU37_24785) 85771..85962 - 192 WP_000398480.1 hypothetical protein -
NMU37_RS24795 (NMU37_24790) 86054..86395 - 342 WP_001151575.1 hypothetical protein -
NMU37_RS24800 (NMU37_24795) 86768..87160 + 393 WP_000341066.1 hypothetical protein -
NMU37_RS24805 (NMU37_24800) 87764..88057 + 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
NMU37_RS24810 (NMU37_24805) 88062..89387 + 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
NMU37_RS24815 (NMU37_24810) 89448..89654 + 207 WP_000134171.1 hypothetical protein -
NMU37_RS24820 (NMU37_24815) 89756..90166 + 411 WP_000985911.1 hypothetical protein -
NMU37_RS24825 (NMU37_24820) 90179..90994 + 816 WP_001572439.1 HNH endonuclease signature motif containing protein -
NMU37_RS24830 (NMU37_24825) 91248..91673 + 426 WP_001043843.1 hypothetical protein -
NMU37_RS24835 (NMU37_24830) 92127..92362 + 236 Protein_88 type I restriction-modification system subunit M N-terminal domain-containing protein -
NMU37_RS24840 (NMU37_24835) 92417..92716 + 300 WP_001572440.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid mcr-1.1 / fosA3 / blaCTX-M-14 / sul1 / oqxA / oqxB - 1..218090 218090
- flank IS/Tn mcr-1.1 - 82211..84955 2744


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50249.20 Da        Isoelectric Point: 6.1927

>T252092 WP_000088046.1 NZ_CP101387:88062-89387 [Salmonella enterica]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10946.35 Da        Isoelectric Point: 10.0925

>AT252092 WP_024136327.1 NZ_CP101387:87764-88057 [Salmonella enterica]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References