Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4415542..4416323 Replicon chromosome
Accession NZ_CP101386
Organism Salmonella enterica strain SC2017100

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag NMU37_RS21685 Protein ID WP_000626099.1
Coordinates 4415542..4416033 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag NMU37_RS21690 Protein ID WP_001110452.1
Coordinates 4416030..4416323 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU37_RS21650 (4411537) 4411537..4412112 + 576 WP_001188509.1 transcriptional regulator -
NMU37_RS21660 (4412383) 4412383..4412460 - 78 Protein_4236 helix-turn-helix domain-containing protein -
NMU37_RS21665 (4412551) 4412551..4412883 - 333 WP_001165471.1 MerR family transcriptional regulator -
NMU37_RS21670 (4412955) 4412955..4413332 + 378 WP_000916345.1 EthD family reductase -
NMU37_RS21675 (4414365) 4414365..4414439 + 75 Protein_4239 porin family protein -
NMU37_RS21680 (4414542) 4414542..4415294 + 753 WP_000842434.1 non-specific acid phosphatase -
NMU37_RS21685 (4415542) 4415542..4416033 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
NMU37_RS21690 (4416030) 4416030..4416323 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
NMU37_RS21695 (4416640) 4416640..4416861 + 222 WP_001576552.1 hypothetical protein -
NMU37_RS21700 (4417126) 4417126..4418001 + 876 WP_000921674.1 AraC family transcriptional regulator -
NMU37_RS21705 (4417998) 4417998..4418285 + 288 WP_001269916.1 transcriptional regulator RtsB -
NMU37_RS21710 (4418308) 4418308..4418523 + 216 WP_001595136.1 hypothetical protein -
NMU37_RS21715 (4418531) 4418531..4418800 + 270 WP_010989096.1 hypothetical protein -
NMU37_RS21720 (4419094) 4419094..4419999 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T252089 WP_000626099.1 NZ_CP101386:c4416033-4415542 [Salmonella enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT252089 WP_001110452.1 NZ_CP101386:c4416323-4416030 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References