Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4286205..4286721 Replicon chromosome
Accession NZ_CP101386
Organism Salmonella enterica strain SC2017100

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag NMU37_RS21010 Protein ID WP_000220578.1
Coordinates 4286205..4286489 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag NMU37_RS21015 Protein ID WP_000212724.1
Coordinates 4286479..4286721 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU37_RS20995 (4281417) 4281417..4283069 + 1653 WP_000155057.1 alpha,alpha-phosphotrehalase -
NMU37_RS21000 (4283478) 4283478..4285616 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
NMU37_RS21005 (4285737) 4285737..4286201 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NMU37_RS21010 (4286205) 4286205..4286489 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NMU37_RS21015 (4286479) 4286479..4286721 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NMU37_RS21020 (4286799) 4286799..4288712 - 1914 WP_001212137.1 BglG family transcription antiterminator -
NMU37_RS21025 (4288729) 4288729..4289469 - 741 WP_000779263.1 KDGP aldolase family protein -
NMU37_RS21030 (4289466) 4289466..4290584 - 1119 WP_001139182.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
NMU37_RS21035 (4290568) 4290568..4291701 - 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T252088 WP_000220578.1 NZ_CP101386:c4286489-4286205 [Salmonella enterica]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT252088 WP_000212724.1 NZ_CP101386:c4286721-4286479 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References