Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3569811..3570431 Replicon chromosome
Accession NZ_CP101386
Organism Salmonella enterica strain SC2017100

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NMU37_RS17720 Protein ID WP_001280991.1
Coordinates 3570213..3570431 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag NMU37_RS17715 Protein ID WP_000344807.1
Coordinates 3569811..3570185 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU37_RS17705 (3564950) 3564950..3566143 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NMU37_RS17710 (3566166) 3566166..3569315 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
NMU37_RS17715 (3569811) 3569811..3570185 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
NMU37_RS17720 (3570213) 3570213..3570431 + 219 WP_001280991.1 HHA domain-containing protein Toxin
NMU37_RS17725 (3570610) 3570610..3571161 + 552 WP_001278792.1 maltose O-acetyltransferase -
NMU37_RS17730 (3571278) 3571278..3571748 + 471 WP_000136181.1 YlaC family protein -
NMU37_RS17735 (3571804) 3571804..3571944 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
NMU37_RS17740 (3571950) 3571950..3572210 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
NMU37_RS17745 (3572435) 3572435..3573985 + 1551 WP_000213139.1 EAL domain-containing protein -
NMU37_RS17755 (3574216) 3574216..3574605 + 390 WP_000961285.1 MGMT family protein -
NMU37_RS17760 (3574638) 3574638..3575207 - 570 WP_000779803.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T252084 WP_001280991.1 NZ_CP101386:3570213-3570431 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT252084 WP_000344807.1 NZ_CP101386:3569811-3570185 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References