Detailed information of TA system TA025208

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 827686..828271
• Replicon: chromosome
• Accession: NC_015458
• Organism: Pusillimonas sp. T7-7

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: PT7_RS18715
• Protein ID: WP_013741813.1
• Coordinates: 828089..828271 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: F4GPE1
• Locus tag: PT7_RS03575
• Protein ID: WP_013741812.1
• Coordinates: 827686..828078 (-)
• Length: 131 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PT7_RS03565	823134..824441	+	1308	WP_013741809.1	ATP-dependent Clp protease ATP-binding subunit ClpX	-
PT7_RS03570	824593..827067	+	2475	WP_013741810.1	endopeptidase La	-
PT7_RS03575	827686..828078	-	393	WP_013741812.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
PT7_RS18715	828089..828271	-	183	WP_013741813.1	type II toxin-antitoxin system HicA family toxin	Toxin
PT7_RS03580	828479..829177	-	699	WP_013741814.1	hypothetical protein	-
PT7_RS03585	829299..829961	-	663	WP_013741815.1	transcriptional repressor LexA	-
PT7_RS03590	830092..831294	-	1203	WP_013741816.1	aspartate/tyrosine/aromatic aminotransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6714.91 Da
• Isoelectric Point: 11.1799

>T25208 WP_013741813.1 NC_015458:c828271-828089 [Pusillimonas sp. T7-7]
MNSKDLIKLLEQAGWQLRGVKGSHHVYRHPTQPGHISVPHPKKDLGIGLVNKLLRQAGMK

Nucleotide

• Length: 183 bp

>T25208 NC_015458:c828271-828089 [Pusillimonas sp. T7-7]
ATGAACAGCAAAGACCTTATCAAGCTGCTTGAACAGGCCGGATGGCAATTACGAGGCGTGAAAGGTTCCCACCACGTCTA
TCGACACCCAACCCAACCTGGGCATATCAGTGTCCCTCACCCCAAGAAAGATCTTGGAATCGGACTGGTTAACAAGCTGC
TGCGTCAAGCTGGAATGAAATAA

Antitoxin

Protein

• Length: 131 a.a.
• Molecular weight: 14080.88 Da
• Isoelectric Point: 3.9870

>AT25208 WP_013741812.1 NC_015458:c828078-827686 [Pusillimonas sp. T7-7]
MKYPIAIEPGNDTTAWGVVAPDLPGCFSAADNGIDEAIENAKEAIALWIEEAIANGEIIPKPSSITDLQMTGEYDGWIWA
IAEVDPALIDDTTERVNITLPRRILALLDQRAKSAGESRSGYIAQMTLTH

Nucleotide

• Length: 393 bp

>AT25208 NC_015458:c828078-827686 [Pusillimonas sp. T7-7]
ATGAAATACCCAATCGCTATCGAACCTGGTAACGACACCACTGCCTGGGGGGTAGTGGCGCCCGATCTTCCTGGCTGCTT
TTCTGCCGCCGATAACGGTATCGACGAAGCCATCGAGAACGCCAAAGAAGCCATCGCCCTGTGGATCGAAGAAGCCATCG
CCAATGGCGAAATCATTCCAAAGCCTTCCAGCATCACCGATCTTCAAATGACCGGCGAGTACGACGGATGGATATGGGCT
ATTGCCGAAGTCGACCCTGCTCTGATCGACGACACCACTGAGCGCGTCAACATCACTCTACCCCGCAGGATTCTTGCCCT
TCTGGATCAGCGCGCCAAGTCTGCAGGTGAAAGCCGATCAGGCTACATAGCACAAATGACGCTCACACACTGA

Structures

Antitoxin

• AlphaFold DB: F4GPE1