Detailed information of TA system TA025208

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 827686..828271
• Replicon: chromosome
• Accession: NC_015458
• Organism: Pusillimonas sp. T7-7

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: PT7_RS18715
• Protein ID: WP_013741813.1
• Coordinates: 828089..828271 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: F4GPE1
• Locus tag: PT7_RS03575
• Protein ID: WP_013741812.1
• Coordinates: 827686..828078 (-)
• Length: 131 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6714.91 Da
• Isoelectric Point: 11.1799

>T25208 WP_013741813.1 NC_015458:c828271-828089 [Pusillimonas sp. T7-7]
MNSKDLIKLLEQAGWQLRGVKGSHHVYRHPTQPGHISVPHPKKDLGIGLVNKLLRQAGMK

Nucleotide

• Length: 183 bp

>T25208 NC_015458:c828271-828089 [Pusillimonas sp. T7-7]
ATGAACAGCAAAGACCTTATCAAGCTGCTTGAACAGGCCGGATGGCAATTACGAGGCGTGAAAGGTTCCCACCACGTCTA
TCGACACCCAACCCAACCTGGGCATATCAGTGTCCCTCACCCCAAGAAAGATCTTGGAATCGGACTGGTTAACAAGCTGC
TGCGTCAAGCTGGAATGAAATAA

Antitoxin

Protein

• Length: 131 a.a.
• Molecular weight: 14080.88 Da
• Isoelectric Point: 3.9870

>AT25208 WP_013741812.1 NC_015458:c828078-827686 [Pusillimonas sp. T7-7]
MKYPIAIEPGNDTTAWGVVAPDLPGCFSAADNGIDEAIENAKEAIALWIEEAIANGEIIPKPSSITDLQMTGEYDGWIWA
IAEVDPALIDDTTERVNITLPRRILALLDQRAKSAGESRSGYIAQMTLTH

Nucleotide

• Length: 393 bp

>AT25208 NC_015458:c828078-827686 [Pusillimonas sp. T7-7]
ATGAAATACCCAATCGCTATCGAACCTGGTAACGACACCACTGCCTGGGGGGTAGTGGCGCCCGATCTTCCTGGCTGCTT
TTCTGCCGCCGATAACGGTATCGACGAAGCCATCGAGAACGCCAAAGAAGCCATCGCCCTGTGGATCGAAGAAGCCATCG
CCAATGGCGAAATCATTCCAAAGCCTTCCAGCATCACCGATCTTCAAATGACCGGCGAGTACGACGGATGGATATGGGCT
ATTGCCGAAGTCGACCCTGCTCTGATCGACGACACCACTGAGCGCGTCAACATCACTCTACCCCGCAGGATTCTTGCCCT
TCTGGATCAGCGCGCCAAGTCTGCAGGTGAAAGCCGATCAGGCTACATAGCACAAATGACGCTCACACACTGA

Structures

Antitoxin

• AlphaFold DB: F4GPE1