Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 951044..951704 Replicon chromosome
Accession NZ_CP101386
Organism Salmonella enterica strain SC2017100

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag NMU37_RS04660 Protein ID WP_000244756.1
Coordinates 951291..951704 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag NMU37_RS04655 Protein ID WP_000351186.1
Coordinates 951044..951310 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU37_RS04635 (946972) 946972..948405 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
NMU37_RS04640 (948564) 948564..948875 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
NMU37_RS04645 (949039) 949039..949698 + 660 WP_000250289.1 hemolysin III family protein -
NMU37_RS04650 (949814) 949814..950794 - 981 WP_000874172.1 tRNA-modifying protein YgfZ -
NMU37_RS04655 (951044) 951044..951310 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
NMU37_RS04660 (951291) 951291..951704 + 414 WP_000244756.1 protein YgfX Toxin
NMU37_RS04665 (951757) 951757..952278 - 522 WP_001055885.1 flavodoxin FldB -
NMU37_RS04670 (952391) 952391..953287 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
NMU37_RS04675 (953311) 953311..954024 + 714 WP_000745625.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NMU37_RS04680 (954030) 954030..955763 + 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T252076 WP_000244756.1 NZ_CP101386:951291-951704 [Salmonella enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT252076 WP_000351186.1 NZ_CP101386:951044-951310 [Salmonella enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References