Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4400030..4400811 Replicon chromosome
Accession NZ_CP101382
Organism Salmonella enterica strain SC2017030

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag NMU36_RS21600 Protein ID WP_000626099.1
Coordinates 4400030..4400521 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag NMU36_RS21605 Protein ID WP_001110452.1
Coordinates 4400518..4400811 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU36_RS21565 (4396025) 4396025..4396600 + 576 WP_001188509.1 transcriptional regulator -
NMU36_RS21575 (4396871) 4396871..4396948 - 78 Protein_4219 helix-turn-helix domain-containing protein -
NMU36_RS21580 (4397039) 4397039..4397371 - 333 WP_001165471.1 MerR family transcriptional regulator -
NMU36_RS21585 (4397443) 4397443..4397820 + 378 WP_000916345.1 EthD family reductase -
NMU36_RS21590 (4398853) 4398853..4398927 + 75 Protein_4222 porin family protein -
NMU36_RS21595 (4399030) 4399030..4399782 + 753 WP_000842434.1 non-specific acid phosphatase -
NMU36_RS21600 (4400030) 4400030..4400521 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
NMU36_RS21605 (4400518) 4400518..4400811 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
NMU36_RS21610 (4401128) 4401128..4401349 + 222 WP_001576552.1 hypothetical protein -
NMU36_RS21615 (4401614) 4401614..4402489 + 876 WP_000921674.1 AraC family transcriptional regulator -
NMU36_RS21620 (4402486) 4402486..4402773 + 288 WP_001269916.1 transcriptional regulator RtsB -
NMU36_RS21625 (4402796) 4402796..4403011 + 216 WP_001595136.1 hypothetical protein -
NMU36_RS21630 (4403019) 4403019..4403288 + 270 WP_010989096.1 hypothetical protein -
NMU36_RS21635 (4403582) 4403582..4404487 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T252069 WP_000626099.1 NZ_CP101382:c4400521-4400030 [Salmonella enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT252069 WP_001110452.1 NZ_CP101382:c4400811-4400518 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References