Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4270684..4271200 Replicon chromosome
Accession NZ_CP101382
Organism Salmonella enterica strain SC2017030

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag NMU36_RS20925 Protein ID WP_000220578.1
Coordinates 4270684..4270968 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag NMU36_RS20930 Protein ID WP_000212724.1
Coordinates 4270958..4271200 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU36_RS20910 (4265896) 4265896..4267548 + 1653 WP_000155057.1 alpha,alpha-phosphotrehalase -
NMU36_RS20915 (4267957) 4267957..4270095 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
NMU36_RS20920 (4270216) 4270216..4270680 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NMU36_RS20925 (4270684) 4270684..4270968 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NMU36_RS20930 (4270958) 4270958..4271200 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NMU36_RS20935 (4271278) 4271278..4273191 - 1914 WP_001212137.1 BglG family transcription antiterminator -
NMU36_RS20940 (4273208) 4273208..4273948 - 741 WP_000779263.1 KDGP aldolase family protein -
NMU36_RS20945 (4273945) 4273945..4275063 - 1119 WP_001139182.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
NMU36_RS20950 (4275047) 4275047..4276180 - 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T252068 WP_000220578.1 NZ_CP101382:c4270968-4270684 [Salmonella enterica]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT252068 WP_000212724.1 NZ_CP101382:c4271200-4270958 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References