Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3557506..3558126 Replicon chromosome
Accession NZ_CP101382
Organism Salmonella enterica strain SC2017030

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NMU36_RS17650 Protein ID WP_001280991.1
Coordinates 3557908..3558126 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag NMU36_RS17645 Protein ID WP_000344807.1
Coordinates 3557506..3557880 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU36_RS17635 (3552645) 3552645..3553838 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NMU36_RS17640 (3553861) 3553861..3557010 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
NMU36_RS17645 (3557506) 3557506..3557880 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
NMU36_RS17650 (3557908) 3557908..3558126 + 219 WP_001280991.1 HHA domain-containing protein Toxin
NMU36_RS17655 (3558305) 3558305..3558856 + 552 WP_001278792.1 maltose O-acetyltransferase -
NMU36_RS17660 (3558973) 3558973..3559443 + 471 WP_000136181.1 YlaC family protein -
NMU36_RS17665 (3559499) 3559499..3559639 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
NMU36_RS17670 (3559645) 3559645..3559905 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
NMU36_RS17675 (3560130) 3560130..3561680 + 1551 WP_000213139.1 EAL domain-containing protein -
NMU36_RS17685 (3561911) 3561911..3562300 + 390 WP_000961285.1 MGMT family protein -
NMU36_RS17690 (3562333) 3562333..3562902 - 570 WP_000779803.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T252064 WP_001280991.1 NZ_CP101382:3557908-3558126 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT252064 WP_000344807.1 NZ_CP101382:3557506-3557880 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References