Detailed information of TA system TA025205

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-MazE
• Location: 2310017..2310645
• Replicon: chromosome
• Accession: NC_015437
• Organism: Selenomonas sputigena ATCC 35185

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: C9LYK0
• Locus tag: SELSP_RS10570
• Protein ID: WP_006193926.1
• Coordinates: 2310244..2310645 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: C9LYK1
• Locus tag: SELSP_RS10565
• Protein ID: WP_006193927.1
• Coordinates: 2310017..2310247 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SELSP_RS10550	2306408..2307946	-	1539	WP_006193930.1	hypothetical protein	-
SELSP_RS10555	2308116..2308631	-	516	WP_006193929.1	cysteine hydrolase	-
SELSP_RS10560	2308854..2309984	+	1131	WP_013741027.1	D-alanyl-D-alanine carboxypeptidase	-
SELSP_RS10565	2310017..2310247	+	231	WP_006193927.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
SELSP_RS10570	2310244..2310645	+	402	WP_006193926.1	type II toxin-antitoxin system VapC family toxin	Toxin
SELSP_RS10575	2310675..2311838	+	1164	WP_006193925.1	YibE/F family protein	-
SELSP_RS10580	2311850..2312281	+	432	WP_006193924.1	PaaI family thioesterase	-
SELSP_RS10585	2312427..2313887	+	1461	WP_006193923.1	nicotinate phosphoribosyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-124)

Antitoxin

• SpoVT-AbrB domain (7-49)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14790.29 Da
• Isoelectric Point: 7.7755

>T25205 WP_006193926.1 NC_015437:2310244-2310645 [Selenomonas sputigena ATCC 35185]
MRYMLDTNICIYAIKNQPTQVLQRLRSHVSEGISISSVTLAELEHGVCKSAYPERNAAALLQFLIILQILPFDAVAAREY
GNICAALQKKGTPIGTMDMLIAAHARAEKLILVTNNVREFARVPDLPIENWAQ

Nucleotide

• Length: 402 bp

>T25205 NC_015437:2310244-2310645 [Selenomonas sputigena ATCC 35185]
ATGAGATATATGCTAGATACCAACATCTGCATCTATGCAATAAAAAACCAACCGACGCAGGTACTGCAACGCCTTCGATC
ACATGTTTCTGAAGGAATTTCCATATCATCGGTCACATTGGCGGAATTGGAACATGGTGTCTGCAAAAGTGCCTATCCGG
AAAGAAACGCTGCCGCTCTGCTGCAATTTTTAATCATTTTGCAAATTTTACCGTTTGATGCTGTAGCAGCAAGGGAATAC
GGCAACATTTGTGCTGCACTGCAAAAGAAAGGCACTCCGATTGGAACAATGGATATGTTGATTGCTGCACACGCACGCGC
AGAAAAGTTGATCTTGGTCACGAATAATGTACGAGAATTTGCTCGCGTGCCGGATTTACCAATAGAAAACTGGGCACAAT
AA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8818.03 Da
• Isoelectric Point: 5.6580

>AT25205 WP_006193927.1 NC_015437:2310017-2310247 [Selenomonas sputigena ATCC 35185]
METAKLFRNGQNQAVRLPPRFRFSGDEVFIQQLGEAVLLVPKNDVWKTFLNGIHSFSEDFFEHGRDVEIISPREVL

Nucleotide

• Length: 231 bp

>AT25205 NC_015437:2310017-2310247 [Selenomonas sputigena ATCC 35185]
ATGGAAACAGCAAAATTATTCCGAAATGGGCAAAACCAAGCCGTTCGCTTACCCCCAAGATTCCGTTTCAGTGGCGATGA
AGTATTCATTCAACAGCTCGGTGAGGCTGTTCTCCTTGTCCCAAAGAATGATGTCTGGAAAACTTTTCTCAATGGTATTC
ACAGCTTCTCCGAGGATTTCTTTGAACATGGCAGAGATGTAGAAATCATTTCACCGAGGGAAGTCCTATGA

Structures

Toxin

• AlphaFold DB: C9LYK0

Antitoxin

• AlphaFold DB: C9LYK1