252046

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4439735..4440516 Replicon chromosome
Accession NZ_CP101379
Organism Salmonella enterica strain SC2016290

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag NMU35_RS21855 Protein ID WP_000626099.1
Coordinates 4439735..4440226 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag NMU35_RS21860 Protein ID WP_001110452.1
Coordinates 4440223..4440516 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU35_RS21815 (4434921) 4434921..4435163 - 243 WP_197603740.1 hypothetical protein -
NMU35_RS21820 (4435160) 4435160..4435516 - 357 WP_033567083.1 hypothetical protein -
NMU35_RS21825 (4435513) 4435513..4436385 - 873 WP_033567082.1 ParA family protein -
NMU35_RS21830 (4436576) 4436576..4436653 - 78 Protein_4270 helix-turn-helix domain-containing protein -
NMU35_RS21835 (4436744) 4436744..4437076 - 333 WP_001165471.1 MerR family transcriptional regulator -
NMU35_RS21840 (4437148) 4437148..4437525 + 378 WP_000916345.1 EthD family reductase -
NMU35_RS21845 (4438558) 4438558..4438632 + 75 Protein_4273 porin family protein -
NMU35_RS21850 (4438735) 4438735..4439487 + 753 WP_000842434.1 non-specific acid phosphatase -
NMU35_RS21855 (4439735) 4439735..4440226 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
NMU35_RS21860 (4440223) 4440223..4440516 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
NMU35_RS21865 (4440833) 4440833..4441054 + 222 WP_001576552.1 hypothetical protein -
NMU35_RS21870 (4441319) 4441319..4442194 + 876 WP_000921674.1 AraC family transcriptional regulator -
NMU35_RS21875 (4442191) 4442191..4442478 + 288 WP_001269916.1 transcriptional regulator RtsB -
NMU35_RS21880 (4442501) 4442501..4442716 + 216 WP_001595136.1 hypothetical protein -
NMU35_RS21885 (4442724) 4442724..4442993 + 270 WP_010989096.1 hypothetical protein -
NMU35_RS21890 (4443287) 4443287..4444192 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T252046 WP_000626099.1 NZ_CP101379:c4440226-4439735 [Salmonella enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT252046 WP_001110452.1 NZ_CP101379:c4440516-4440223 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
AlphaFold DB A0A5I1DGA4

References