Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4229657..4230173 Replicon chromosome
Accession NZ_CP101379
Organism Salmonella enterica strain SC2016290

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag NMU35_RS20750 Protein ID WP_000220578.1
Coordinates 4229657..4229941 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag NMU35_RS20755 Protein ID WP_000212724.1
Coordinates 4229931..4230173 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU35_RS20735 (4224869) 4224869..4226521 + 1653 WP_000155057.1 alpha,alpha-phosphotrehalase -
NMU35_RS20740 (4226930) 4226930..4229068 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
NMU35_RS20745 (4229189) 4229189..4229653 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NMU35_RS20750 (4229657) 4229657..4229941 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NMU35_RS20755 (4229931) 4229931..4230173 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NMU35_RS20760 (4230251) 4230251..4232164 - 1914 WP_001212137.1 BglG family transcription antiterminator -
NMU35_RS20765 (4232181) 4232181..4232921 - 741 WP_000779263.1 KDGP aldolase family protein -
NMU35_RS20770 (4232918) 4232918..4234036 - 1119 WP_001139182.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
NMU35_RS20775 (4234020) 4234020..4235153 - 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T252045 WP_000220578.1 NZ_CP101379:c4229941-4229657 [Salmonella enterica]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT252045 WP_000212724.1 NZ_CP101379:c4230173-4229931 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References