Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4135396..4135972 Replicon chromosome
Accession NZ_CP101379
Organism Salmonella enterica strain SC2016290

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag NMU35_RS20355 Protein ID WP_001131963.1
Coordinates 4135685..4135972 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag NMU35_RS20350 Protein ID WP_000063142.1
Coordinates 4135396..4135698 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU35_RS20335 (4131906) 4131906..4134056 + 2151 WP_000379927.1 pyruvate/proton symporter BtsT -
NMU35_RS20340 (4134151) 4134151..4134354 + 204 WP_000460616.1 YbdD/YjiX family protein -
NMU35_RS20345 (4134365) 4134365..4135321 + 957 WP_000187839.1 GTPase -
NMU35_RS20350 (4135396) 4135396..4135698 - 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
NMU35_RS20355 (4135685) 4135685..4135972 - 288 WP_001131963.1 BrnT family toxin Toxin
NMU35_RS20360 (4136241) 4136241..4137155 - 915 WP_000290512.1 restriction endonuclease -
NMU35_RS20365 (4137353) 4137353..4140862 + 3510 WP_001043484.1 type I restriction-modification system endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T252044 WP_001131963.1 NZ_CP101379:c4135972-4135685 [Salmonella enterica]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT252044 WP_000063142.1 NZ_CP101379:c4135698-4135396 [Salmonella enterica]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
PDB 7VD7
AlphaFold DB A0A4D6PB01

References