252041

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3516484..3517104 Replicon chromosome
Accession NZ_CP101379
Organism Salmonella enterica strain SC2016290

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NMU35_RS17475 Protein ID WP_001280991.1
Coordinates 3516886..3517104 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag NMU35_RS17470 Protein ID WP_000344807.1
Coordinates 3516484..3516858 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU35_RS17460 (3511623) 3511623..3512816 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NMU35_RS17465 (3512839) 3512839..3515988 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
NMU35_RS17470 (3516484) 3516484..3516858 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
NMU35_RS17475 (3516886) 3516886..3517104 + 219 WP_001280991.1 HHA domain-containing protein Toxin
NMU35_RS17480 (3517283) 3517283..3517834 + 552 WP_001278792.1 maltose O-acetyltransferase -
NMU35_RS17485 (3517951) 3517951..3518421 + 471 WP_000136181.1 YlaC family protein -
NMU35_RS17490 (3518477) 3518477..3518617 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
NMU35_RS17495 (3518623) 3518623..3518883 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
NMU35_RS17500 (3519108) 3519108..3520658 + 1551 WP_000213139.1 EAL domain-containing protein -
NMU35_RS17510 (3520889) 3520889..3521278 + 390 WP_000961285.1 MGMT family protein -
NMU35_RS17515 (3521311) 3521311..3521880 - 570 WP_000779803.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T252041 WP_001280991.1 NZ_CP101379:3516886-3517104 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT252041 WP_000344807.1 NZ_CP101379:3516484-3516858 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References