Detailed information of TA system TA025204

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 2203935..2204419
• Replicon: chromosome
• Accession: NC_015437
• Organism: Selenomonas sputigena ATCC 35185

Toxin (Protein)

• Gene name: relE
• Uniprot ID: C9LYU5
• Locus tag: SELSP_RS10150
• Protein ID: WP_006194026.1
• Coordinates: 2204153..2204419 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: F4EX28
• Locus tag: SELSP_RS10145
• Protein ID: WP_013741006.1
• Coordinates: 2203935..2204156 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SELSP_RS10130	2200507..2201703	+	1197	WP_006193208.1	helix-turn-helix domain-containing protein	-
SELSP_RS10135	2202010..2202894	-	885	WP_006194030.1	Hsp33 family molecular chaperone HslO	-
SELSP_RS10140	2202983..2203534	-	552	WP_006194029.1	hypothetical protein	-
SELSP_RS10145	2203935..2204156	+	222	WP_013741006.1	hypothetical protein	Antitoxin
SELSP_RS10150	2204153..2204419	+	267	WP_006194026.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SELSP_RS10155	2204571..2205479	+	909	WP_006194025.1	1-phosphofructokinase	-
SELSP_RS10160	2205509..2207449	+	1941	WP_006194024.1	fructose-specific PTS transporter subunit EIIC	-
SELSP_RS10165	2207504..2207866	+	363	WP_006194023.1	metalloregulator ArsR/SmtB family transcription factor	-
SELSP_RS10170	2208128..2208688	+	561	WP_006194022.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-88)

Antitoxin

• Protein of unknown function DUF6290 (1-68)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10465.18 Da
• Isoelectric Point: 10.2842

>T25204 WP_006194026.1 NC_015437:2204153-2204419 [Selenomonas sputigena ATCC 35185]
VKSYQLIYSERAKKDVKKLDPYTKQMIKSWIEKRLLHSENPRAHGKALTGNHKGEWRYRIGDYRLICAIEDERLVILALA
LGHRREVY

Nucleotide

• Length: 267 bp

>T25204 NC_015437:2204153-2204419 [Selenomonas sputigena ATCC 35185]
GTGAAATCCTATCAATTAATTTACTCCGAGCGTGCAAAGAAAGATGTCAAGAAACTCGATCCATACACCAAGCAGATGAT
CAAGTCGTGGATCGAGAAGCGACTGCTGCACTCGGAAAATCCTCGTGCGCACGGCAAGGCGCTCACGGGAAACCACAAGG
GCGAATGGCGCTACCGCATCGGCGACTACCGTCTGATCTGCGCCATTGAGGACGAGCGGCTCGTCATCCTCGCCCTCGCC
CTCGGGCACAGGCGCGAGGTGTATTGA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8483.39 Da
• Isoelectric Point: 4.0649

>AT25204 WP_013741006.1 NC_015437:2203935-2204156 [Selenomonas sputigena ATCC 35185]
MSFSIRLTDTERALAESYAKLHALSLAEAFKRALFEKIEDEYDIALADEAYEEYLANPTTYSHEEFWNDVMTP

Nucleotide

• Length: 222 bp

>AT25204 NC_015437:2203935-2204156 [Selenomonas sputigena ATCC 35185]
ATGAGCTTTTCAATCCGACTGACGGACACGGAGCGGGCGCTCGCCGAAAGCTACGCGAAGCTGCACGCGCTCTCGCTCGC
CGAAGCATTCAAGCGGGCGCTCTTCGAAAAGATCGAGGACGAGTACGACATCGCGCTTGCCGACGAAGCGTATGAGGAGT
ACCTGGCAAACCCTACGACATACTCTCACGAGGAATTCTGGAATGATGTGATGACGCCGTGA

Structures

Toxin

• AlphaFold DB: C9LYU5

Antitoxin

• AlphaFold DB: F4EX28