Detailed information of TA system TA025203

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 671143..671693
• Replicon: chromosome
• Accession: NC_015437
• Organism: Selenomonas sputigena ATCC 35185

Toxin (Protein)

• Gene name: relE
• Uniprot ID: C9LX73
• Locus tag: SELSP_RS02950
• Protein ID: WP_006193400.1
• Coordinates: 671143..671424 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: C9LX72
• Locus tag: SELSP_RS02955
• Protein ID: WP_006193399.1
• Coordinates: 671421..671693 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SELSP_RS02945	669175..670818	+	1644	WP_013740631.1	ShlB/FhaC/HecB family hemolysin secretion/activation protein	-
SELSP_RS02950	671143..671424	-	282	WP_006193400.1	type II toxin-antitoxin system YafQ family toxin	Toxin
SELSP_RS02955	671421..671693	-	273	WP_006193399.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
SELSP_RS02960	672012..672359	+	348	WP_006193397.1	histidine triad nucleotide-binding protein	-
SELSP_RS02965	672478..672660	+	183	WP_006193396.1	30S ribosomal protein S21	-
SELSP_RS02970	672763..674475	-	1713	WP_013740632.1	ribonuclease J	-
SELSP_RS11885	674681..674950	-	270	WP_006193394.1	helix-turn-helix transcriptional regulator	-
SELSP_RS12080	674979..675161	-	183	WP_081443697.1	type II toxin-antitoxin system RelE/ParE family toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-68)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10988.63 Da
• Isoelectric Point: 8.8544

>T25203 WP_006193400.1 NC_015437:c671424-671143 [Selenomonas sputigena ATCC 35185]
MTYRIKFTSAYKKSYKRAKKRGLNLKLLDDVIEVLRQGHKLNAKYRDHELHGNWAGFRECHVQPDWLLVYLVENDILTLT
LVETGTHADIFDE

Nucleotide

• Length: 282 bp

>T25203 NC_015437:c671424-671143 [Selenomonas sputigena ATCC 35185]
ATGACTTATCGCATCAAATTCACCAGCGCTTATAAGAAAAGTTACAAGCGTGCCAAAAAACGCGGTTTGAATCTCAAACT
ATTAGATGATGTTATCGAGGTATTGAGACAGGGACATAAGCTAAATGCCAAATACCGTGACCACGAACTCCATGGAAATT
GGGCGGGGTTTCGCGAGTGCCATGTTCAACCTGATTGGTTATTGGTGTACCTCGTTGAAAATGACATCCTAACCTTGACC
CTTGTCGAAACTGGAACTCATGCAGATATATTCGATGAATAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10112.64 Da
• Isoelectric Point: 5.8125

>AT25203 WP_006193399.1 NC_015437:c671693-671421 [Selenomonas sputigena ATCC 35185]
MSTVPTQIRIDRNIKEQAGILFSGLGLDMSGAVNMFLHQCVLRGGIPFSIEMPRYKQSTLAAMEEARRISRDPNVPGYDN
MDDLKRALEE

Nucleotide

• Length: 273 bp

>AT25203 NC_015437:c671693-671421 [Selenomonas sputigena ATCC 35185]
ATGTCAACTGTCCCTACTCAAATAAGAATTGACCGTAATATAAAAGAACAGGCCGGAATTTTGTTTTCTGGGCTGGGCTT
GGATATGTCTGGTGCCGTTAATATGTTTCTGCATCAATGCGTTCTTCGTGGAGGCATCCCTTTTTCTATCGAAATGCCGC
GTTATAAGCAAAGCACTTTGGCCGCTATGGAAGAAGCAAGAAGAATCTCCCGCGACCCTAATGTTCCCGGCTACGACAAT
ATGGACGACTTGAAGAGGGCATTGGAAGAATGA

Structures

Toxin

• AlphaFold DB: C9LX73

Antitoxin

• AlphaFold DB: C9LX72