Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 108321..108964 Replicon plasmid pSC2016091-mcr-116k
Accession NZ_CP101378
Organism Salmonella enterica strain SC2016091

Toxin (Protein)


Gene name vagD Uniprot ID B1LRW4
Locus tag NMU34_RS25235 Protein ID WP_001044768.1
Coordinates 108548..108964 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D2WFK3
Locus tag NMU34_RS25230 Protein ID WP_001261287.1
Coordinates 108321..108551 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU34_RS25210 (103501) 103501..104634 - 1134 WP_000545983.1 DUF3800 domain-containing protein -
NMU34_RS25215 (104897) 104897..106534 - 1638 WP_223201785.1 hypothetical protein -
NMU34_RS25220 (106585) 106585..107415 - 831 WP_223201786.1 hypothetical protein -
NMU34_RS25225 (107467) 107467..108015 - 549 WP_039002808.1 hypothetical protein -
NMU34_RS25230 (108321) 108321..108551 + 231 WP_001261287.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NMU34_RS25235 (108548) 108548..108964 + 417 WP_001044768.1 type II toxin-antitoxin system VapC family toxin Toxin
NMU34_RS25240 (109126) 109126..111264 - 2139 WP_039002805.1 AAA family ATPase -
NMU34_RS25245 (111729) 111729..112724 + 996 WP_000246636.1 hypothetical protein -
NMU34_RS25250 (112767) 112767..113660 + 894 WP_001553853.1 S-4TM family putative pore-forming effector -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaCTX-M-55 / qnrS1 / mcr-3.1 / aac(3)-IId - 1..116686 116686
- flank IS/Tn - - 113797..114174 377


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15197.66 Da        Isoelectric Point: 7.7805

>T252029 WP_001044768.1 NZ_CP101378:108548-108964 [Salmonella enterica]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDEFCARLDAILPWDRA
AVDATTKIKVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPDLVLEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8815.90 Da        Isoelectric Point: 4.3775

>AT252029 WP_001261287.1 NZ_CP101378:108321-108551 [Salmonella enterica]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLEYEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A606Q844

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QFC4

References