252023

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4441594..4442375 Replicon chromosome
Accession NZ_CP101376
Organism Salmonella enterica strain SC2016091

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag NMU34_RS21820 Protein ID WP_000626099.1
Coordinates 4441594..4442085 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag NMU34_RS21825 Protein ID WP_001110452.1
Coordinates 4442082..4442375 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU34_RS21780 (4436780) 4436780..4437022 - 243 WP_197603740.1 hypothetical protein -
NMU34_RS21785 (4437019) 4437019..4437375 - 357 WP_033567083.1 hypothetical protein -
NMU34_RS21790 (4437372) 4437372..4438244 - 873 WP_033567082.1 ParA family protein -
NMU34_RS21795 (4438435) 4438435..4438512 - 78 Protein_4263 helix-turn-helix domain-containing protein -
NMU34_RS21800 (4438603) 4438603..4438935 - 333 WP_001165471.1 MerR family transcriptional regulator -
NMU34_RS21805 (4439007) 4439007..4439384 + 378 WP_000916345.1 EthD family reductase -
NMU34_RS21810 (4440417) 4440417..4440491 + 75 Protein_4266 porin family protein -
NMU34_RS21815 (4440594) 4440594..4441346 + 753 WP_000842434.1 non-specific acid phosphatase -
NMU34_RS21820 (4441594) 4441594..4442085 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
NMU34_RS21825 (4442082) 4442082..4442375 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
NMU34_RS21830 (4442692) 4442692..4442913 + 222 WP_001576552.1 hypothetical protein -
NMU34_RS21835 (4443178) 4443178..4444053 + 876 WP_000921674.1 AraC family transcriptional regulator -
NMU34_RS21840 (4444050) 4444050..4444337 + 288 WP_001269916.1 transcriptional regulator RtsB -
NMU34_RS21845 (4444360) 4444360..4444575 + 216 WP_001595136.1 hypothetical protein -
NMU34_RS21850 (4444583) 4444583..4444852 + 270 WP_010989096.1 hypothetical protein -
NMU34_RS21855 (4445146) 4445146..4446051 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T252023 WP_000626099.1 NZ_CP101376:c4442085-4441594 [Salmonella enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT252023 WP_001110452.1 NZ_CP101376:c4442375-4442082 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
AlphaFold DB A0A5I1DGA4

References