Detailed information of TA system TA025202

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 509347..509885
• Replicon: chromosome
• Accession: NC_015437
• Organism: Selenomonas sputigena ATCC 35185

Toxin (Protein)

• Gene name: relE
• Uniprot ID: C9LXN7
• Locus tag: SELSP_RS11860
• Protein ID: WP_006193587.1
• Coordinates: 509347..509622 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: F4EYL4
• Locus tag: SELSP_RS02235
• Protein ID: WP_013740585.1
• Coordinates: 509619..509885 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SELSP_RS02220	506081..506581	+	501	WP_037367896.1	acetolactate synthase small subunit	-
SELSP_RS02225	506627..507766	+	1140	WP_013740583.1	D-alanyl-D-alanine carboxypeptidase	-
SELSP_RS02230	507787..509211	+	1425	WP_013740584.1	[FeFe] hydrogenase H-cluster radical SAM maturase HydG	-
SELSP_RS11860	509347..509622	-	276	WP_006193587.1	type II toxin-antitoxin system YafQ family toxin	Toxin
SELSP_RS02235	509619..509885	-	267	WP_013740585.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
SELSP_RS02240	510190..510486	+	297	WP_006193585.1	helix-turn-helix domain-containing protein	-
SELSP_RS02245	510703..510897	+	195	WP_013740587.1	sulfur carrier protein ThiS	-
SELSP_RS02250	510964..511761	+	798	WP_006193583.1	thiazole synthase	-
SELSP_RS02255	511758..513014	+	1257	WP_006193582.1	2-iminoacetate synthase ThiH	-
SELSP_RS02260	513007..513606	+	600	WP_006193581.1	thiamine phosphate synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-91)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-75)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10485.23 Da
• Isoelectric Point: 9.1381

>T25202 WP_006193587.1 NC_015437:c509622-509347 [Selenomonas sputigena ATCC 35185]
MKYKIIPTARFRKDVKTAAKRGLPLCRLEEIVDQLAAGTPLPERNRDHALTGTFAGYRECHILPDWLLVYRIDNEILTLL
LHRTGTHSDLF

Nucleotide

• Length: 276 bp

>T25202 NC_015437:c509622-509347 [Selenomonas sputigena ATCC 35185]
TTGAAATACAAGATCATCCCCACAGCACGTTTCCGCAAAGACGTAAAAACTGCTGCCAAACGCGGTCTGCCTCTTTGCCG
TCTGGAAGAAATCGTCGACCAGCTTGCCGCTGGAACGCCATTGCCCGAAAGGAATCGCGACCATGCACTTACAGGTACAT
TCGCAGGATATCGGGAATGTCATATATTGCCAGATTGGTTGCTAGTCTATCGTATTGATAACGAAATTCTCACTTTACTC
CTTCATCGAACGGGTACACACAGCGATTTATTTTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9847.36 Da
• Isoelectric Point: 5.0508

>AT25202 WP_013740585.1 NC_015437:c509885-509619 [Selenomonas sputigena ATCC 35185]
MPSTMIRVRMDSALKAQTDAALASMGLNMSVAVNAMARQILRQGRLPFELYATNPETMAALQEAEEIRRNPENFKSYASA
HEMMEDIL

Nucleotide

• Length: 267 bp

>AT25202 NC_015437:c509885-509619 [Selenomonas sputigena ATCC 35185]
ATGCCTTCGACCATGATACGAGTCCGCATGGATTCAGCGTTAAAAGCCCAAACGGATGCCGCACTCGCCAGCATGGGACT
CAACATGTCCGTCGCGGTCAACGCGATGGCGCGTCAGATCCTGCGCCAAGGAAGGCTTCCTTTTGAGCTTTATGCAACAA
ATCCCGAAACGATGGCCGCTCTGCAGGAGGCCGAAGAGATACGCAGAAATCCCGAGAATTTCAAATCCTATGCTTCAGCA
CATGAAATGATGGAGGATATTCTTTGA

Structures

Toxin

• AlphaFold DB: C9LXN7

Antitoxin

• AlphaFold DB: F4EYL4