252018

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3518338..3518958 Replicon chromosome
Accession NZ_CP101376
Organism Salmonella enterica strain SC2016091

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NMU34_RS17440 Protein ID WP_001280991.1
Coordinates 3518740..3518958 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag NMU34_RS17435 Protein ID WP_000344807.1
Coordinates 3518338..3518712 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU34_RS17425 (3513477) 3513477..3514670 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NMU34_RS17430 (3514693) 3514693..3517842 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
NMU34_RS17435 (3518338) 3518338..3518712 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
NMU34_RS17440 (3518740) 3518740..3518958 + 219 WP_001280991.1 HHA domain-containing protein Toxin
NMU34_RS17445 (3519137) 3519137..3519688 + 552 WP_001278792.1 maltose O-acetyltransferase -
NMU34_RS17450 (3519805) 3519805..3520275 + 471 WP_000136181.1 YlaC family protein -
NMU34_RS17455 (3520331) 3520331..3520471 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
NMU34_RS17460 (3520477) 3520477..3520737 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
NMU34_RS17465 (3520962) 3520962..3522512 + 1551 WP_000213139.1 EAL domain-containing protein -
NMU34_RS17475 (3522743) 3522743..3523132 + 390 WP_000961285.1 MGMT family protein -
NMU34_RS17480 (3523165) 3523165..3523734 - 570 WP_000779803.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T252018 WP_001280991.1 NZ_CP101376:3518740-3518958 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT252018 WP_000344807.1 NZ_CP101376:3518338-3518712 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References