Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4999462..5000243 Replicon chromosome
Accession NZ_CP101375
Organism Salmonella enterica strain SC2016090

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag NMU33_RS24605 Protein ID WP_000626099.1
Coordinates 4999462..4999953 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag NMU33_RS24610 Protein ID WP_001110452.1
Coordinates 4999950..5000243 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU33_RS24570 (4995457) 4995457..4996032 + 576 WP_001188509.1 transcriptional regulator -
NMU33_RS24580 (4996303) 4996303..4996380 - 78 Protein_4801 helix-turn-helix domain-containing protein -
NMU33_RS24585 (4996471) 4996471..4996803 - 333 WP_001165471.1 MerR family transcriptional regulator -
NMU33_RS24590 (4996875) 4996875..4997252 + 378 WP_000916345.1 EthD family reductase -
NMU33_RS24595 (4998285) 4998285..4998359 + 75 Protein_4804 porin family protein -
NMU33_RS24600 (4998462) 4998462..4999214 + 753 WP_000842434.1 non-specific acid phosphatase -
NMU33_RS24605 (4999462) 4999462..4999953 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
NMU33_RS24610 (4999950) 4999950..5000243 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
NMU33_RS24615 (5000560) 5000560..5000781 + 222 WP_001576552.1 hypothetical protein -
NMU33_RS24620 (5001046) 5001046..5001921 + 876 WP_000921674.1 AraC family transcriptional regulator -
NMU33_RS24625 (5001918) 5001918..5002205 + 288 WP_001269916.1 transcriptional regulator RtsB -
NMU33_RS24630 (5002228) 5002228..5002443 + 216 WP_001595136.1 hypothetical protein -
NMU33_RS24635 (5002451) 5002451..5002720 + 270 WP_010989096.1 hypothetical protein -
NMU33_RS24640 (5003014) 5003014..5003919 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T252006 WP_000626099.1 NZ_CP101375:c4999953-4999462 [Salmonella enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT252006 WP_001110452.1 NZ_CP101375:c5000243-4999950 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References