Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 778877..779637 Replicon chromosome
Accession NZ_CP101375
Organism Salmonella enterica strain SC2016090

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag NMU33_RS03825 Protein ID WP_000533909.1
Coordinates 779152..779637 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag NMU33_RS03820 Protein ID WP_000965886.1
Coordinates 778877..779164 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU33_RS03795 (774172) 774172..774474 + 303 WP_000605590.1 YsaB family lipoprotein -
NMU33_RS03800 (774613) 774613..775524 + 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
NMU33_RS03805 (775534) 775534..777603 + 2070 WP_001291736.1 glycine--tRNA ligase subunit beta -
NMU33_RS03810 (777785) 777785..778060 + 276 Protein_741 IS3 family transposase -
NMU33_RS03815 (778232) 778232..778699 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
NMU33_RS03820 (778877) 778877..779164 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
NMU33_RS03825 (779152) 779152..779637 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
NMU33_RS03830 (780009) 780009..780548 - 540 WP_000047149.1 copper-binding periplasmic metallochaperone CueP -
NMU33_RS03835 (780722) 780722..780934 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
NMU33_RS03840 (781223) 781223..781513 - 291 WP_000455790.1 HTH-type transcriptional regulator -
NMU33_RS03845 (781952) 781952..782662 + 711 WP_000190524.1 DUF3053 domain-containing protein -
NMU33_RS03850 (782712) 782712..783686 - 975 WP_000804674.1 glyoxylate/hydroxypyruvate reductase GhrB -
NMU33_RS03855 (783905) 783905..784567 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T251990 WP_000533909.1 NZ_CP101375:779152-779637 [Salmonella enterica]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT251990 WP_000965886.1 NZ_CP101375:778877-779164 [Salmonella enterica]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References