Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1368857..1369340 Replicon chromosome
Accession NC_015433
Organism Streptococcus suis ST3

Toxin (Protein)


Gene name relE Uniprot ID A0A0Z8BIZ7
Locus tag SSUST3_RS06695 Protein ID WP_009910443.1
Coordinates 1368857..1369117 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Z8BIX7
Locus tag SSUST3_RS06700 Protein ID WP_012775256.1
Coordinates 1369119..1369340 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSUST3_RS06670 1364242..1365471 - 1230 WP_009910437.1 tetratricopeptide repeat protein -
SSUST3_RS06675 1365461..1366627 - 1167 WP_002935690.1 AI-2E family transporter -
SSUST3_RS06680 1366763..1367767 + 1005 WP_009910438.1 lactonase family protein -
SSUST3_RS06685 1367831..1368016 + 186 WP_002935693.1 hypothetical protein -
SSUST3_RS06690 1368049..1368690 - 642 WP_002935700.1 HAD family hydrolase -
SSUST3_RS06695 1368857..1369117 - 261 WP_009910443.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SSUST3_RS06700 1369119..1369340 - 222 WP_012775256.1 hypothetical protein Antitoxin
SSUST3_RS06705 1369650..1370957 - 1308 WP_002935704.1 phosphopyruvate hydratase -
SSUST3_RS06710 1371107..1371559 + 453 WP_013730449.1 DUF1694 domain-containing protein -
SSUST3_RS06715 1371569..1371796 - 228 WP_002935708.1 hypothetical protein -
SSUST3_RS06720 1371787..1372914 - 1128 WP_002935718.1 glycerate kinase -
SSUST3_RS06725 1373022..1373672 + 651 WP_002935722.1 HAD family hydrolase -
SSUST3_RS06730 1373703..1374338 - 636 WP_002935723.1 phosphoserine phosphatase SerB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10270.78 Da        Isoelectric Point: 9.6925

>T25199 WP_009910443.1 NC_015433:c1369117-1368857 [Streptococcus suis ST3]
MYHLEYSKKAQKQIKKLDRQIQRLLFAWIDKHLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKLVILALEFG
HRKDVY

Download         Length: 261 bp

>T25199 NC_015433:c1369117-1368857 [Streptococcus suis ST3]
ATGTATCATTTAGAGTATTCTAAAAAGGCTCAAAAGCAAATTAAGAAATTAGATAGGCAAATTCAGAGGTTGTTGTTTGC
TTGGATTGATAAACACTTAGAAGGGACTGATAATCCACGCGCCAATGGTAAAGGTTTGACAGGCAATCATGCTAACGAGT
GGCGTTATCGTATCGGAGATTACCGACTGATTTGCGATATTCAAGATGATAAGTTGGTTATTTTAGCACTTGAGTTTGGA
CATCGTAAAGATGTCTATTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8566.55 Da        Isoelectric Point: 4.4791

>AT25199 WP_012775256.1 NC_015433:c1369340-1369119 [Streptococcus suis ST3]
MSTVTIRLNQEEEVFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYDEYKADPETISHADFKKELGL

Download         Length: 222 bp

>AT25199 NC_015433:c1369340-1369119 [Streptococcus suis ST3]
ATGAGTACAGTGACAATCAGATTAAATCAAGAAGAAGAAGTATTCTTTAAAAGCTATGCACAATTAACAGGTCAAAGTCT
TTCTAGCCTTTTTAAGAAAGCTTTGGAGCGTGATATTGAAGATGAGTATGATTTAAAAATCTATCATCAAGCTTATGATG
AGTACAAAGCAGATCCAGAAACAATTAGTCATGCTGATTTTAAGAAAGAGCTAGGATTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8BIZ7

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8BIX7

References