Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 418274..419897 Replicon chromosome
Accession NZ_CP101375
Organism Salmonella enterica strain SC2016090

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag NMU33_RS02045 Protein ID WP_000088046.1
Coordinates 418274..419599 (-) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag NMU33_RS02050 Protein ID WP_024136327.1
Coordinates 419604..419897 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU33_RS02015 (414258) 414258..415115 - 858 WP_000784387.1 HNH endonuclease signature motif containing protein -
NMU33_RS02020 (415131) 415131..415439 - 309 WP_001224687.1 hypothetical protein -
NMU33_RS02025 (415988) 415988..416413 - 426 WP_001043843.1 hypothetical protein -
NMU33_RS02030 (416667) 416667..417482 - 816 WP_053276223.1 HNH endonuclease signature motif containing protein -
NMU33_RS02035 (417495) 417495..417905 - 411 WP_000985911.1 hypothetical protein -
NMU33_RS02040 (418007) 418007..418213 - 207 WP_000134171.1 hypothetical protein -
NMU33_RS02045 (418274) 418274..419599 - 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
NMU33_RS02050 (419604) 419604..419897 - 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
NMU33_RS02055 (420501) 420501..420893 - 393 WP_000341066.1 hypothetical protein -
NMU33_RS02060 (421266) 421266..421607 + 342 WP_001151575.1 hypothetical protein -
NMU33_RS02065 (421699) 421699..421890 + 192 WP_000398480.1 hypothetical protein -
NMU33_RS02070 (421940) 421940..422221 + 282 WP_000077926.1 hypothetical protein -
NMU33_RS02075 (422562) 422562..422693 - 132 WP_000374059.1 hypothetical protein -
NMU33_RS02080 (422784) 422784..424025 - 1242 WP_001053338.1 VWA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element sul3 / ant(3'')-Ia / cmlA1 / aadA2 / dfrA12 / floR / sul2 / aac(3)-IVa / fosA3 / blaCTX-M-14 / mph(A) / mcr-1.1 / oqxB / oqxA / sul1 - 258748..635358 376610


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50249.20 Da        Isoelectric Point: 6.1927

>T251989 WP_000088046.1 NZ_CP101375:c419599-418274 [Salmonella enterica]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10946.35 Da        Isoelectric Point: 10.0925

>AT251989 WP_024136327.1 NZ_CP101375:c419897-419604 [Salmonella enterica]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References