251982

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4392899..4393680 Replicon chromosome
Accession NZ_CP101373
Organism Salmonella enterica strain SC2016042

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag NMU32_RS21555 Protein ID WP_000626099.1
Coordinates 4392899..4393390 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag NMU32_RS21560 Protein ID WP_001110452.1
Coordinates 4393387..4393680 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU32_RS21520 (4388894) 4388894..4389469 + 576 WP_001188509.1 transcriptional regulator -
NMU32_RS21530 (4389740) 4389740..4389817 - 78 Protein_4210 helix-turn-helix domain-containing protein -
NMU32_RS21535 (4389908) 4389908..4390240 - 333 WP_001165471.1 MerR family transcriptional regulator -
NMU32_RS21540 (4390312) 4390312..4390689 + 378 WP_000916345.1 EthD family reductase -
NMU32_RS21545 (4391722) 4391722..4391796 + 75 Protein_4213 porin family protein -
NMU32_RS21550 (4391899) 4391899..4392651 + 753 WP_000842434.1 non-specific acid phosphatase -
NMU32_RS21555 (4392899) 4392899..4393390 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
NMU32_RS21560 (4393387) 4393387..4393680 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
NMU32_RS21565 (4393997) 4393997..4394218 + 222 WP_001576552.1 hypothetical protein -
NMU32_RS21570 (4394483) 4394483..4395358 + 876 WP_000921674.1 AraC family transcriptional regulator -
NMU32_RS21575 (4395355) 4395355..4395642 + 288 WP_001269916.1 transcriptional regulator RtsB -
NMU32_RS21580 (4395665) 4395665..4395880 + 216 WP_001595136.1 hypothetical protein -
NMU32_RS21585 (4395888) 4395888..4396157 + 270 WP_010989096.1 hypothetical protein -
NMU32_RS21590 (4396451) 4396451..4397356 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T251982 WP_000626099.1 NZ_CP101373:c4393390-4392899 [Salmonella enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT251982 WP_001110452.1 NZ_CP101373:c4393680-4393387 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References