Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4263562..4264078 Replicon chromosome
Accession NZ_CP101373
Organism Salmonella enterica strain SC2016042

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag NMU32_RS20880 Protein ID WP_000220578.1
Coordinates 4263562..4263846 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag NMU32_RS20885 Protein ID WP_000212724.1
Coordinates 4263836..4264078 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU32_RS20865 (4258774) 4258774..4260426 + 1653 WP_000155057.1 alpha,alpha-phosphotrehalase -
NMU32_RS20870 (4260835) 4260835..4262973 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
NMU32_RS20875 (4263094) 4263094..4263558 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NMU32_RS20880 (4263562) 4263562..4263846 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NMU32_RS20885 (4263836) 4263836..4264078 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NMU32_RS20890 (4264156) 4264156..4266069 - 1914 WP_001212137.1 BglG family transcription antiterminator -
NMU32_RS20895 (4266086) 4266086..4266826 - 741 WP_000779263.1 KDGP aldolase family protein -
NMU32_RS20900 (4266823) 4266823..4267941 - 1119 WP_001139182.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
NMU32_RS20905 (4267925) 4267925..4269058 - 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T251981 WP_000220578.1 NZ_CP101373:c4263846-4263562 [Salmonella enterica]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT251981 WP_000212724.1 NZ_CP101373:c4264078-4263836 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References