Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1016353..1016839 Replicon chromosome
Accession NC_015433
Organism Streptococcus suis ST3

Toxin (Protein)


Gene name relE Uniprot ID A0A0K2E5U8
Locus tag SSUST3_RS04995 Protein ID WP_002935012.1
Coordinates 1016353..1016610 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0K2E5B0
Locus tag SSUST3_RS05000 Protein ID WP_002935014.1
Coordinates 1016600..1016839 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSUST3_RS04975 1011987..1013057 + 1071 WP_002935006.1 tyrosine recombinase XerS -
SSUST3_RS04980 1013127..1014635 - 1509 WP_013730362.1 phosphoglucomutase -
SSUST3_RS04985 1014711..1015652 - 942 WP_002935009.1 sensor histidine kinase -
SSUST3_RS04990 1015649..1016314 - 666 WP_009909826.1 response regulator transcription factor -
SSUST3_RS04995 1016353..1016610 - 258 WP_002935012.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SSUST3_RS05000 1016600..1016839 - 240 WP_002935014.1 hypothetical protein Antitoxin
SSUST3_RS05005 1016931..1018901 - 1971 WP_013730363.1 FtsX-like permease family protein -
SSUST3_RS05010 1018902..1019654 - 753 WP_002935019.1 ABC transporter ATP-binding protein -
SSUST3_RS05015 1019671..1020054 - 384 WP_002935021.1 NisI/SpaI family lantibiotic immunity lipoprotein -
SSUST3_RS10695 1020067..1020207 - 141 WP_002935023.1 hypothetical protein -
SSUST3_RS05025 1020306..1021040 - 735 WP_013730364.1 beta-carotene 15,15'-monooxygenase -
SSUST3_RS10700 1021053..1021190 - 138 WP_002935027.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-75)

Antitoxin

Protein of unknown function DUF6290

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9849.52 Da        Isoelectric Point: 10.7134

>T25198 WP_002935012.1 NC_015433:c1016610-1016353 [Streptococcus suis ST3]
MSYKVILSAKAQKQIRKMDKTAASLILRYLYKHIDGCDNPRQYGKALTANRSGQWRYRIGNYRVIVNIEDDKLIVTSIKM
RNGSI

Download         Length: 258 bp

>T25198 NC_015433:c1016610-1016353 [Streptococcus suis ST3]
TTGAGTTATAAGGTTATTTTGTCTGCTAAGGCCCAAAAGCAAATTCGAAAGATGGATAAAACCGCTGCAAGTTTGATTTT
GCGCTATCTCTACAAGCATATTGACGGTTGCGACAACCCTAGACAATACGGAAAAGCCTTGACTGCTAATCGTTCTGGCC
AATGGCGCTATCGTATCGGCAATTACAGGGTTATCGTTAATATTGAAGATGATAAATTGATTGTGACAAGCATAAAAATG
AGAAATGGAAGTATATAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8924.19 Da        Isoelectric Point: 3.9191

>AT25198 WP_002935014.1 NC_015433:c1016839-1016600 [Streptococcus suis ST3]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADVAWAEYQADLANRIEPMTLEQMAEELGIEL

Download         Length: 240 bp

>AT25198 NC_015433:c1016839-1016600 [Streptococcus suis ST3]
ATGGCAGCTATTACATTGAAAGTTTCTGAGCAGGACAAGCTCTTTATGCAGGCTATGGCAAAGTTTGAAGGTGTCAGTTT
GTCAGAACTCATTCGGACTAAAACCCTTGAAGCCCTTGAAGACGAGTACGATGCGCGTGTGGCAGACGTTGCTTGGGCAG
AATACCAAGCAGACTTGGCGAATAGAATTGAGCCGATGACATTAGAACAAATGGCTGAGGAGTTGGGCATTGAGTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K2E5U8

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E5B0

References