Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3550384..3551004 Replicon chromosome
Accession NZ_CP101373
Organism Salmonella enterica strain SC2016042

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NMU32_RS17605 Protein ID WP_001280991.1
Coordinates 3550786..3551004 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag NMU32_RS17600 Protein ID WP_000344807.1
Coordinates 3550384..3550758 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU32_RS17590 (3545523) 3545523..3546716 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NMU32_RS17595 (3546739) 3546739..3549888 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
NMU32_RS17600 (3550384) 3550384..3550758 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
NMU32_RS17605 (3550786) 3550786..3551004 + 219 WP_001280991.1 HHA domain-containing protein Toxin
NMU32_RS17610 (3551183) 3551183..3551734 + 552 WP_001278792.1 maltose O-acetyltransferase -
NMU32_RS17615 (3551851) 3551851..3552321 + 471 WP_000136181.1 YlaC family protein -
NMU32_RS17620 (3552377) 3552377..3552517 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
NMU32_RS17625 (3552523) 3552523..3552783 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
NMU32_RS17630 (3553008) 3553008..3554558 + 1551 WP_000213139.1 EAL domain-containing protein -
NMU32_RS17640 (3554789) 3554789..3555178 + 390 WP_000961285.1 MGMT family protein -
NMU32_RS17645 (3555211) 3555211..3555780 - 570 WP_000779803.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T251977 WP_001280991.1 NZ_CP101373:3550786-3551004 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT251977 WP_000344807.1 NZ_CP101373:3550384-3550758 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References