Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 919068..919728 Replicon chromosome
Accession NZ_CP101373
Organism Salmonella enterica strain SC2016042

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag NMU32_RS04465 Protein ID WP_000244756.1
Coordinates 919315..919728 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag NMU32_RS04460 Protein ID WP_000351186.1
Coordinates 919068..919334 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMU32_RS04440 (914996) 914996..916429 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
NMU32_RS04445 (916588) 916588..916899 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
NMU32_RS04450 (917063) 917063..917722 + 660 WP_000250289.1 hemolysin III family protein -
NMU32_RS04455 (917838) 917838..918818 - 981 WP_000874172.1 tRNA-modifying protein YgfZ -
NMU32_RS04460 (919068) 919068..919334 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
NMU32_RS04465 (919315) 919315..919728 + 414 WP_000244756.1 protein YgfX Toxin
NMU32_RS04470 (919781) 919781..920302 - 522 WP_001055885.1 flavodoxin FldB -
NMU32_RS04475 (920415) 920415..921311 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
NMU32_RS04480 (921335) 921335..922048 + 714 WP_000745625.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NMU32_RS04485 (922054) 922054..923787 + 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T251969 WP_000244756.1 NZ_CP101373:919315-919728 [Salmonella enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT251969 WP_000351186.1 NZ_CP101373:919068-919334 [Salmonella enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References